Type II transmembrane serine protease gene variants associate with breast cancer.

Type II transmembrane serine proteases (TTSPs) are related to tumor growth, invasion, and metastasis in cancer. Genetic variants in these genes may alter their function, leading to cancer onset and progression, and affect patient outcome. Here, 464 breast cancer cases and 370 controls were genotyped...

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Autores principales:	Kaisa Luostari, Jaana M Hartikainen, Maria Tengström, Jorma J Palvimo, Vesa Kataja, Arto Mannermaa, Veli-Matti Kosma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60d8d1f823cd4bec995d3ad95a823deb
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spelling	oai:doaj.org-article:60d8d1f823cd4bec995d3ad95a823deb2021-11-25T06:08:13ZType II transmembrane serine protease gene variants associate with breast cancer.1932-620310.1371/journal.pone.0102519https://doaj.org/article/60d8d1f823cd4bec995d3ad95a823deb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25029565/?tool=EBIhttps://doaj.org/toc/1932-6203Type II transmembrane serine proteases (TTSPs) are related to tumor growth, invasion, and metastasis in cancer. Genetic variants in these genes may alter their function, leading to cancer onset and progression, and affect patient outcome. Here, 464 breast cancer cases and 370 controls were genotyped for 82 single-nucleotide polymorphisms covering eight genes. Association of the genotypes was estimated against breast cancer risk, breast cancer-specific survival, and survival in different treatment groups, and clinicopathological variables. SNPs in TMPRSS3 (rs3814903 and rs11203200), TMPRSS7 (rs1844925), and HGF (rs5745752) associated significantly with breast cancer risk (Ptrend = 0.008-0.042). SNPs in TMPRSS1 (rs12151195 and rs12461158), TMPRSS2 (rs2276205), TMPRSS3 (rs3814903), and TMPRSS7 (rs2399403) associated with prognosis (P = 0.004-0.046). When estimating the combined effect of the variants, the risk of breast cancer was higher with 4-5 alleles present compared to 0-2 alleles (P = 0.0001; OR, 2.34; 95% CI, 1.39-3.94). Women with 6-8 survival-associating alleles had a 3.3 times higher risk of dying of breast cancer compared to women with 1-3 alleles (P = 0.001; HR, 3.30; 95% CI, 1.58-6.88). The results demonstrate the combined effect of variants in TTSPs and their related genes in breast cancer risk and patient outcome. Functional analysis of these variants will lead to further understanding of this gene family, which may improve individualized risk estimation and development of new strategies for treatment of breast cancer.Kaisa LuostariJaana M HartikainenMaria TengströmJorma J PalvimoVesa KatajaArto MannermaaVeli-Matti KosmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102519 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaisa Luostari Jaana M Hartikainen Maria Tengström Jorma J Palvimo Vesa Kataja Arto Mannermaa Veli-Matti Kosma Type II transmembrane serine protease gene variants associate with breast cancer.
description	Type II transmembrane serine proteases (TTSPs) are related to tumor growth, invasion, and metastasis in cancer. Genetic variants in these genes may alter their function, leading to cancer onset and progression, and affect patient outcome. Here, 464 breast cancer cases and 370 controls were genotyped for 82 single-nucleotide polymorphisms covering eight genes. Association of the genotypes was estimated against breast cancer risk, breast cancer-specific survival, and survival in different treatment groups, and clinicopathological variables. SNPs in TMPRSS3 (rs3814903 and rs11203200), TMPRSS7 (rs1844925), and HGF (rs5745752) associated significantly with breast cancer risk (Ptrend = 0.008-0.042). SNPs in TMPRSS1 (rs12151195 and rs12461158), TMPRSS2 (rs2276205), TMPRSS3 (rs3814903), and TMPRSS7 (rs2399403) associated with prognosis (P = 0.004-0.046). When estimating the combined effect of the variants, the risk of breast cancer was higher with 4-5 alleles present compared to 0-2 alleles (P = 0.0001; OR, 2.34; 95% CI, 1.39-3.94). Women with 6-8 survival-associating alleles had a 3.3 times higher risk of dying of breast cancer compared to women with 1-3 alleles (P = 0.001; HR, 3.30; 95% CI, 1.58-6.88). The results demonstrate the combined effect of variants in TTSPs and their related genes in breast cancer risk and patient outcome. Functional analysis of these variants will lead to further understanding of this gene family, which may improve individualized risk estimation and development of new strategies for treatment of breast cancer.
format	article
author	Kaisa Luostari Jaana M Hartikainen Maria Tengström Jorma J Palvimo Vesa Kataja Arto Mannermaa Veli-Matti Kosma
author_facet	Kaisa Luostari Jaana M Hartikainen Maria Tengström Jorma J Palvimo Vesa Kataja Arto Mannermaa Veli-Matti Kosma
author_sort	Kaisa Luostari
title	Type II transmembrane serine protease gene variants associate with breast cancer.
title_short	Type II transmembrane serine protease gene variants associate with breast cancer.
title_full	Type II transmembrane serine protease gene variants associate with breast cancer.
title_fullStr	Type II transmembrane serine protease gene variants associate with breast cancer.
title_full_unstemmed	Type II transmembrane serine protease gene variants associate with breast cancer.
title_sort	type ii transmembrane serine protease gene variants associate with breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/60d8d1f823cd4bec995d3ad95a823deb
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Type II transmembrane serine protease gene variants associate with breast cancer.

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