Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

In skeletal muscle progenitors, EZH2 maintains myogenic genes in a repressed state, but during differentiation its levels are reduced via unknown mechanisms. Here the authors show that during myogenesis, p38α kinase phosphorylates EZH2 and targets it for degradation by the ubiquitin ligase PRAJA1.

Guardado en:

Detalles Bibliográficos
Autores principales:	Silvia Consalvi, Arianna Brancaccio, Alessandra Dall’Agnese, Pier Lorenzo Puri, Daniela Palacios
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60dc0d431e904aa1aa98c1f73411a251
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60dc0d431e904aa1aa98c1f73411a251
record_format	dspace
spelling	oai:doaj.org-article:60dc0d431e904aa1aa98c1f73411a2512021-12-02T17:06:15ZPraja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation10.1038/ncomms139562041-1723https://doaj.org/article/60dc0d431e904aa1aa98c1f73411a2512017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13956https://doaj.org/toc/2041-1723In skeletal muscle progenitors, EZH2 maintains myogenic genes in a repressed state, but during differentiation its levels are reduced via unknown mechanisms. Here the authors show that during myogenesis, p38α kinase phosphorylates EZH2 and targets it for degradation by the ubiquitin ligase PRAJA1.Silvia ConsalviArianna BrancaccioAlessandra Dall’AgnesePier Lorenzo PuriDaniela PalaciosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Consalvi Arianna Brancaccio Alessandra Dall’Agnese Pier Lorenzo Puri Daniela Palacios Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
description	In skeletal muscle progenitors, EZH2 maintains myogenic genes in a repressed state, but during differentiation its levels are reduced via unknown mechanisms. Here the authors show that during myogenesis, p38α kinase phosphorylates EZH2 and targets it for degradation by the ubiquitin ligase PRAJA1.
format	article
author	Silvia Consalvi Arianna Brancaccio Alessandra Dall’Agnese Pier Lorenzo Puri Daniela Palacios
author_facet	Silvia Consalvi Arianna Brancaccio Alessandra Dall’Agnese Pier Lorenzo Puri Daniela Palacios
author_sort	Silvia Consalvi
title	Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
title_short	Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
title_full	Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
title_fullStr	Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
title_full_unstemmed	Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
title_sort	praja1 e3 ubiquitin ligase promotes skeletal myogenesis through degradation of ezh2 upon p38α activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60dc0d431e904aa1aa98c1f73411a251
work_keys_str_mv	AT silviaconsalvi praja1e3ubiquitinligasepromotesskeletalmyogenesisthroughdegradationofezh2uponp38aactivation AT ariannabrancaccio praja1e3ubiquitinligasepromotesskeletalmyogenesisthroughdegradationofezh2uponp38aactivation AT alessandradallagnese praja1e3ubiquitinligasepromotesskeletalmyogenesisthroughdegradationofezh2uponp38aactivation AT pierlorenzopuri praja1e3ubiquitinligasepromotesskeletalmyogenesisthroughdegradationofezh2uponp38aactivation AT danielapalacios praja1e3ubiquitinligasepromotesskeletalmyogenesisthroughdegradationofezh2uponp38aactivation
_version_	1718381676226150400

Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation

Ejemplares similares