Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca.

<h4>Background</h4>TGF-β is a pleiotropic cytokine that can have pro- or anti-inflammatory effects depending on the context. Elevated levels of bioactive TGF-β1 in tears and elevated TGF-β1mRNA transcripts in conjunctiva and minor salivary glands of human Sjögren's Syndrome patients...

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Autores principales: Cintia S De Paiva, Eugene A Volpe, Niral B Gandhi, Xiaobo Zhang, Xiaofen Zheng, John D Pitcher, William J Farley, Michael E Stern, Jerry Y Niederkorn, De-Quan Li, Richard A Flavell, Stephen C Pflugfelder
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/60dc5f26b15249c1a0229a4f9063c6a7
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