Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.

Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety...

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Autores principales:	Nicholas R G Silver, Rachel Ward-Flanagan, Clayton T Dickson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60e0aeb726894bcaacbc1f61010c0292
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spelling	oai:doaj.org-article:60e0aeb726894bcaacbc1f61010c02922021-12-02T20:13:31ZLong-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.1932-620310.1371/journal.pone.0258939https://doaj.org/article/60e0aeb726894bcaacbc1f61010c02922021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258939https://doaj.org/toc/1932-6203Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety of physiological and pathophysiological processes. As urethane is typically administered as a single-bolus dose, it is unclear the stability of peripheral physiological functions both within and between brain-states under urethane anesthesia. In this present study, we recorded respiration rate and heart rate concurrently with local field potentials from the neocortex and hippocampus to determine the stability of peripheral physiological functions within and between brain-states under urethane anesthesia. Our data shows electroencephalographic characteristics and breathing rate are remarkable stable over long-term recordings within minor reductions in heart rate on the same time scale. Our findings indicate that the use of urethane to model peripheral physiological functions associated with changing brain states are stable during long duration experiments.Nicholas R G SilverRachel Ward-FlanaganClayton T DicksonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicholas R G Silver Rachel Ward-Flanagan Clayton T Dickson Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
description	Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety of physiological and pathophysiological processes. As urethane is typically administered as a single-bolus dose, it is unclear the stability of peripheral physiological functions both within and between brain-states under urethane anesthesia. In this present study, we recorded respiration rate and heart rate concurrently with local field potentials from the neocortex and hippocampus to determine the stability of peripheral physiological functions within and between brain-states under urethane anesthesia. Our data shows electroencephalographic characteristics and breathing rate are remarkable stable over long-term recordings within minor reductions in heart rate on the same time scale. Our findings indicate that the use of urethane to model peripheral physiological functions associated with changing brain states are stable during long duration experiments.
format	article
author	Nicholas R G Silver Rachel Ward-Flanagan Clayton T Dickson
author_facet	Nicholas R G Silver Rachel Ward-Flanagan Clayton T Dickson
author_sort	Nicholas R G Silver
title	Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
title_short	Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
title_full	Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
title_fullStr	Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
title_full_unstemmed	Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
title_sort	long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/60e0aeb726894bcaacbc1f61010c0292
work_keys_str_mv	AT nicholasrgsilver longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia AT rachelwardflanagan longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia AT claytontdickson longtermstabilityofphysiologicalsignalswithinfluctuationsofbrainstateunderurethaneanesthesia
_version_	1718374768704487424

Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia.

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