Mitochondrial mutations drive prostate cancer aggression

In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clini...

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Autores principales:	Julia F. Hopkins, Veronica Y. Sabelnykova, Joachim Weischenfeldt, Ronald Simon, Jennifer A. Aguiar, Rached Alkallas, Lawrence E. Heisler, Junyan Zhang, John D. Watson, Melvin L. K. Chua, Michael Fraser, Francesco Favero, Chris Lawerenz, Christoph Plass, Guido Sauter, John D. McPherson, Theodorus van der Kwast, Jan Korbel, Thorsten Schlomm, Robert G. Bristow, Paul C. Boutros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60e16080a49e4b41a40aef4ed8595ea3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:60e16080a49e4b41a40aef4ed8595ea32021-12-02T17:06:24ZMitochondrial mutations drive prostate cancer aggression10.1038/s41467-017-00377-y2041-1723https://doaj.org/article/60e16080a49e4b41a40aef4ed8595ea32017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00377-yhttps://doaj.org/toc/2041-1723In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.Julia F. HopkinsVeronica Y. SabelnykovaJoachim WeischenfeldtRonald SimonJennifer A. AguiarRached AlkallasLawrence E. HeislerJunyan ZhangJohn D. WatsonMelvin L. K. ChuaMichael FraserFrancesco FaveroChris LawerenzChristoph PlassGuido SauterJohn D. McPhersonTheodorus van der KwastJan KorbelThorsten SchlommRobert G. BristowPaul C. BoutrosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia F. Hopkins Veronica Y. Sabelnykova Joachim Weischenfeldt Ronald Simon Jennifer A. Aguiar Rached Alkallas Lawrence E. Heisler Junyan Zhang John D. Watson Melvin L. K. Chua Michael Fraser Francesco Favero Chris Lawerenz Christoph Plass Guido Sauter John D. McPherson Theodorus van der Kwast Jan Korbel Thorsten Schlomm Robert G. Bristow Paul C. Boutros Mitochondrial mutations drive prostate cancer aggression
description	In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.
format	article
author	Julia F. Hopkins Veronica Y. Sabelnykova Joachim Weischenfeldt Ronald Simon Jennifer A. Aguiar Rached Alkallas Lawrence E. Heisler Junyan Zhang John D. Watson Melvin L. K. Chua Michael Fraser Francesco Favero Chris Lawerenz Christoph Plass Guido Sauter John D. McPherson Theodorus van der Kwast Jan Korbel Thorsten Schlomm Robert G. Bristow Paul C. Boutros
author_facet	Julia F. Hopkins Veronica Y. Sabelnykova Joachim Weischenfeldt Ronald Simon Jennifer A. Aguiar Rached Alkallas Lawrence E. Heisler Junyan Zhang John D. Watson Melvin L. K. Chua Michael Fraser Francesco Favero Chris Lawerenz Christoph Plass Guido Sauter John D. McPherson Theodorus van der Kwast Jan Korbel Thorsten Schlomm Robert G. Bristow Paul C. Boutros
author_sort	Julia F. Hopkins
title	Mitochondrial mutations drive prostate cancer aggression
title_short	Mitochondrial mutations drive prostate cancer aggression
title_full	Mitochondrial mutations drive prostate cancer aggression
title_fullStr	Mitochondrial mutations drive prostate cancer aggression
title_full_unstemmed	Mitochondrial mutations drive prostate cancer aggression
title_sort	mitochondrial mutations drive prostate cancer aggression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60e16080a49e4b41a40aef4ed8595ea3
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_version_	1718381613697466368

Mitochondrial mutations drive prostate cancer aggression

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