Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.

<h4>Background</h4>Fibroblast growth factor (FGF)-23 levels rise as kidney function declines. Whether elevated FGF-23 levels are associated with an increased risk for contrast-associated acute kidney injury (CA-AKI) and major adverse cardiovascular events (MACE) in patients undergoing co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shao-Sung Huang, Po-Hsun Huang, Hsin-Bang Leu, Tao-Cheng Wu, Jaw-Wen Chen, Shing-Jong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60e1c8b098124ba8929e42fa5239e4af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60e1c8b098124ba8929e42fa5239e4af
record_format	dspace
spelling	oai:doaj.org-article:60e1c8b098124ba8929e42fa5239e4af2021-12-02T20:04:53ZSignificance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.1932-620310.1371/journal.pone.0254835https://doaj.org/article/60e1c8b098124ba8929e42fa5239e4af2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254835https://doaj.org/toc/1932-6203<h4>Background</h4>Fibroblast growth factor (FGF)-23 levels rise as kidney function declines. Whether elevated FGF-23 levels are associated with an increased risk for contrast-associated acute kidney injury (CA-AKI) and major adverse cardiovascular events (MACE) in patients undergoing coronary angiography remain uncertain.<h4>Methods</h4>In total, 492 patients receiving coronary angiography were enrolled. Their serum FGF-23 levels were measured before administration of contrast media. The occurrence of CA-AKI was defined as a rise in serum creatinine of 0.5 mg/dL or a 25% increase from the baseline value within 48 h after the procedure. All patients were followed up for at least 1 year or until the occurrence of MACE including death, nonfatal myocardial infarction (MI), and ischemic stroke.<h4>Results</h4>Overall, CA-AKI occurred in 41 (8.3%) patients. During a median follow-up of 2.6 years, there were 24 deaths, 3 nonfatal MIs, and 7 ischemic strokes. Compared with those in the lowest FGF-23 tertile, individuals in the highest FGF-23 tertile had a significantly higher incidence of CA-AKI (P < 0.001) and lower incidence of MACE-free survival (P = 0.001). In multivariate regression analysis, higher FGF-23 level was found to be independently associated with a graded risk for CA-AKI (OR per doubling, 1.90; 95% CI 1.48-2.44) and MACE (HR per doubling, 1.25; 95% CI 1.02-1.52).<h4>Conclusions</h4>Elevated FGF-23 levels were associated with an increased risk for CA-AKI and future MACE among patients undergoing coronary angiography. FGF-23 may play a role in early diagnosis of CA-AKI and predicting clinical outcomes after coronary angiography.Shao-Sung HuangPo-Hsun HuangHsin-Bang LeuTao-Cheng WuJaw-Wen ChenShing-Jong LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254835 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shao-Sung Huang Po-Hsun Huang Hsin-Bang Leu Tao-Cheng Wu Jaw-Wen Chen Shing-Jong Lin Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
description	<h4>Background</h4>Fibroblast growth factor (FGF)-23 levels rise as kidney function declines. Whether elevated FGF-23 levels are associated with an increased risk for contrast-associated acute kidney injury (CA-AKI) and major adverse cardiovascular events (MACE) in patients undergoing coronary angiography remain uncertain.<h4>Methods</h4>In total, 492 patients receiving coronary angiography were enrolled. Their serum FGF-23 levels were measured before administration of contrast media. The occurrence of CA-AKI was defined as a rise in serum creatinine of 0.5 mg/dL or a 25% increase from the baseline value within 48 h after the procedure. All patients were followed up for at least 1 year or until the occurrence of MACE including death, nonfatal myocardial infarction (MI), and ischemic stroke.<h4>Results</h4>Overall, CA-AKI occurred in 41 (8.3%) patients. During a median follow-up of 2.6 years, there were 24 deaths, 3 nonfatal MIs, and 7 ischemic strokes. Compared with those in the lowest FGF-23 tertile, individuals in the highest FGF-23 tertile had a significantly higher incidence of CA-AKI (P < 0.001) and lower incidence of MACE-free survival (P = 0.001). In multivariate regression analysis, higher FGF-23 level was found to be independently associated with a graded risk for CA-AKI (OR per doubling, 1.90; 95% CI 1.48-2.44) and MACE (HR per doubling, 1.25; 95% CI 1.02-1.52).<h4>Conclusions</h4>Elevated FGF-23 levels were associated with an increased risk for CA-AKI and future MACE among patients undergoing coronary angiography. FGF-23 may play a role in early diagnosis of CA-AKI and predicting clinical outcomes after coronary angiography.
format	article
author	Shao-Sung Huang Po-Hsun Huang Hsin-Bang Leu Tao-Cheng Wu Jaw-Wen Chen Shing-Jong Lin
author_facet	Shao-Sung Huang Po-Hsun Huang Hsin-Bang Leu Tao-Cheng Wu Jaw-Wen Chen Shing-Jong Lin
author_sort	Shao-Sung Huang
title	Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
title_short	Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
title_full	Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
title_fullStr	Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
title_full_unstemmed	Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
title_sort	significance of serum fgf-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/60e1c8b098124ba8929e42fa5239e4af
work_keys_str_mv	AT shaosunghuang significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography AT pohsunhuang significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography AT hsinbangleu significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography AT taochengwu significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography AT jawwenchen significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography AT shingjonglin significanceofserumfgf23forriskassessmentofcontrastassociatedacutekidneyinjuryandclinicaloutcomesinpatientsundergoingcoronaryangiography
_version_	1718375545667846144

Significance of serum FGF-23 for risk assessment of contrast-associated acute kidney injury and clinical outcomes in patients undergoing coronary angiography.

Ejemplares similares