Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy

Terry G Coursey, Cintia S de PaivaCullen Eye Institute, Baylor College of Medicine, Houston, TX, USAAbstract: Dry eye from Sjögren’s syndrome is a multifactorial disease that results in dysfunction of the lacrimal functional unit. Studies have shown changes in tear composition, i...

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Autores principales:	Coursey TG, de Paiva CS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/60e49f0045af457db0ed19988b573eca
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spelling	oai:doaj.org-article:60e49f0045af457db0ed19988b573eca2021-12-02T08:08:29ZManaging Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy1177-5483https://doaj.org/article/60e49f0045af457db0ed19988b573eca2014-08-01T00:00:00Zhttp://www.dovepress.com/managing-sjoumlgrenrsquos-syndrome-and-non-sjoumlgren-syndrome-dry-eye-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Terry G Coursey, Cintia S de PaivaCullen Eye Institute, Baylor College of Medicine, Houston, TX, USAAbstract: Dry eye from Sjögren’s syndrome is a multifactorial disease that results in dysfunction of the lacrimal functional unit. Studies have shown changes in tear composition, including inflammatory cytokines, chemokines, and metalloproteinase. T-lymphocytes have been shown to increase in the conjunctiva and lacrimal glands in patient and animal models. This inflammation is in part responsible for the pathogenesis of the disease, which results in symptoms of eye irritation, ocular surface epithelial disease, and loss of corneal barrier function. There are a number of anti-inflammatory approaches for treating this disease. The current study reviews details of immune response and anti–inflammatory therapies used to control this disease.Keywords: keratoconjunctivitis sicca, SS, cyclosporin A, steroids, dry eye, Sjögren’s SyndromeCoursey TGde Paiva CSDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1447-1458 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Coursey TG de Paiva CS Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
description	Terry G Coursey, Cintia S de PaivaCullen Eye Institute, Baylor College of Medicine, Houston, TX, USAAbstract: Dry eye from Sjögren’s syndrome is a multifactorial disease that results in dysfunction of the lacrimal functional unit. Studies have shown changes in tear composition, including inflammatory cytokines, chemokines, and metalloproteinase. T-lymphocytes have been shown to increase in the conjunctiva and lacrimal glands in patient and animal models. This inflammation is in part responsible for the pathogenesis of the disease, which results in symptoms of eye irritation, ocular surface epithelial disease, and loss of corneal barrier function. There are a number of anti-inflammatory approaches for treating this disease. The current study reviews details of immune response and anti–inflammatory therapies used to control this disease.Keywords: keratoconjunctivitis sicca, SS, cyclosporin A, steroids, dry eye, Sjögren’s Syndrome
format	article
author	Coursey TG de Paiva CS
author_facet	Coursey TG de Paiva CS
author_sort	Coursey TG
title	Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
title_short	Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
title_full	Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
title_fullStr	Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
title_full_unstemmed	Managing Sjögren’s Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy
title_sort	managing sjögren’s syndrome and non-sjögren syndrome dry eye with anti-inflammatory therapy
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/60e49f0045af457db0ed19988b573eca
work_keys_str_mv	AT courseytg managingsjoumlgrenrsquossyndromeandnonsjoumlgrensyndromedryeyewithantiinflammatorytherapy AT depaivacs managingsjoumlgrenrsquossyndromeandnonsjoumlgrensyndromedryeyewithantiinflammatorytherapy
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Managing Sj&ouml;gren&rsquo;s Syndrome and non-Sj&ouml;gren Syndrome dry eye with anti-inflammatory therapy

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