Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination

Abstract We analyzed data from two ongoing COVID-19 longitudinal serological surveys in Orange County, CA., between April 2020 and March 2021. A total of 8476 finger stick blood specimens were collected before and after a vaccination campaign. IgG levels were determined using a multiplex antigen mic...

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Autores principales: Rafael Assis, Aarti Jain, Rie Nakajima, Algis Jasinskas, Saahir Khan, Anton Palma, Daniel M. Parker, Anthony Chau, Specimen Collection Group, Joshua M. Obiero, Delia Tifrea, Amanda Leung, Christina Grabar, Fjolla Muqolli, Ghali Khalil, Jessica Colin Escobar, Jenny Ventura, D. Huw Davies, Bruce Albala, Bernadette Boden-Albala, Sebastian Schubl, Philip L. Felgner
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/60e6b11e268545c68772f092e5b5343b
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spelling oai:doaj.org-article:60e6b11e268545c68772f092e5b5343b2021-11-07T12:06:54ZDistinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination10.1038/s41541-021-00396-32059-0105https://doaj.org/article/60e6b11e268545c68772f092e5b5343b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00396-3https://doaj.org/toc/2059-0105Abstract We analyzed data from two ongoing COVID-19 longitudinal serological surveys in Orange County, CA., between April 2020 and March 2021. A total of 8476 finger stick blood specimens were collected before and after a vaccination campaign. IgG levels were determined using a multiplex antigen microarray containing antigens from SARS-CoV-2, SARS, MERS, Common CoV, and Influenza. Twenty-six percent of specimens from unvaccinated Orange County residents in December 2020 were SARS-CoV-2 seropositive; out of 852 seropositive individuals 77 had symptoms and 9 sought medical care. The antibody response was predominantly against nucleocapsid (NP), full length, and S2 domain of spike. Anti-receptor binding domain (RBD) reactivity was low and not cross-reactive against SARS S1 or SARS RBD. A vaccination campaign at the University of California Irvine Medical Center (UCIMC) started on December, 2020 and 6724 healthcare workers were vaccinated within 3 weeks. Seroprevalence increased from 13% pre-vaccination to 79% post-vaccination in January, 93% in February, and 99% in March. mRNA vaccination induced higher antibody levels than natural exposure, especially against the RBD domain and cross-reactivity against SARS RBD and S1 was observed. Nucleocapsid protein antibodies can be used to distinguish vaccinees to classify pre-exposure to SARS-CoV-2 Previously infected individuals developed higher antibody titers to the vaccine than non pre-exposed individuals. Hospitalized patients in intensive care with severe disease reach significantly higher antibody levels than mild cases, but lower antibody levels compared to the vaccine. These results indicate that mRNA vaccination rapidly induces a much stronger and broader antibody response than SARS-CoV-2 infection.Rafael AssisAarti JainRie NakajimaAlgis JasinskasSaahir KhanAnton PalmaDaniel M. ParkerAnthony ChauSpecimen Collection GroupJoshua M. ObieroDelia TifreaAmanda LeungChristina GrabarFjolla MuqolliGhali KhalilJessica Colin EscobarJenny VenturaD. Huw DaviesBruce AlbalaBernadette Boden-AlbalaSebastian SchublPhilip L. FelgnerNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Rafael Assis
Aarti Jain
Rie Nakajima
Algis Jasinskas
Saahir Khan
Anton Palma
Daniel M. Parker
Anthony Chau
Specimen Collection Group
Joshua M. Obiero
Delia Tifrea
Amanda Leung
Christina Grabar
Fjolla Muqolli
Ghali Khalil
Jessica Colin Escobar
Jenny Ventura
D. Huw Davies
Bruce Albala
Bernadette Boden-Albala
Sebastian Schubl
Philip L. Felgner
Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
description Abstract We analyzed data from two ongoing COVID-19 longitudinal serological surveys in Orange County, CA., between April 2020 and March 2021. A total of 8476 finger stick blood specimens were collected before and after a vaccination campaign. IgG levels were determined using a multiplex antigen microarray containing antigens from SARS-CoV-2, SARS, MERS, Common CoV, and Influenza. Twenty-six percent of specimens from unvaccinated Orange County residents in December 2020 were SARS-CoV-2 seropositive; out of 852 seropositive individuals 77 had symptoms and 9 sought medical care. The antibody response was predominantly against nucleocapsid (NP), full length, and S2 domain of spike. Anti-receptor binding domain (RBD) reactivity was low and not cross-reactive against SARS S1 or SARS RBD. A vaccination campaign at the University of California Irvine Medical Center (UCIMC) started on December, 2020 and 6724 healthcare workers were vaccinated within 3 weeks. Seroprevalence increased from 13% pre-vaccination to 79% post-vaccination in January, 93% in February, and 99% in March. mRNA vaccination induced higher antibody levels than natural exposure, especially against the RBD domain and cross-reactivity against SARS RBD and S1 was observed. Nucleocapsid protein antibodies can be used to distinguish vaccinees to classify pre-exposure to SARS-CoV-2 Previously infected individuals developed higher antibody titers to the vaccine than non pre-exposed individuals. Hospitalized patients in intensive care with severe disease reach significantly higher antibody levels than mild cases, but lower antibody levels compared to the vaccine. These results indicate that mRNA vaccination rapidly induces a much stronger and broader antibody response than SARS-CoV-2 infection.
format article
author Rafael Assis
Aarti Jain
Rie Nakajima
Algis Jasinskas
Saahir Khan
Anton Palma
Daniel M. Parker
Anthony Chau
Specimen Collection Group
Joshua M. Obiero
Delia Tifrea
Amanda Leung
Christina Grabar
Fjolla Muqolli
Ghali Khalil
Jessica Colin Escobar
Jenny Ventura
D. Huw Davies
Bruce Albala
Bernadette Boden-Albala
Sebastian Schubl
Philip L. Felgner
author_facet Rafael Assis
Aarti Jain
Rie Nakajima
Algis Jasinskas
Saahir Khan
Anton Palma
Daniel M. Parker
Anthony Chau
Specimen Collection Group
Joshua M. Obiero
Delia Tifrea
Amanda Leung
Christina Grabar
Fjolla Muqolli
Ghali Khalil
Jessica Colin Escobar
Jenny Ventura
D. Huw Davies
Bruce Albala
Bernadette Boden-Albala
Sebastian Schubl
Philip L. Felgner
author_sort Rafael Assis
title Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
title_short Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
title_full Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
title_fullStr Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
title_full_unstemmed Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccination
title_sort distinct sars-cov-2 antibody reactivity patterns elicited by natural infection and mrna vaccination
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/60e6b11e268545c68772f092e5b5343b
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