Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum

Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.

Guardado en:

Detalles Bibliográficos
Autores principales:	Prem Prakash, Mohammad Zeeshan, Ekta Saini, Azhar Muneer, Sachin Khurana, Bishwanath Kumar Chourasia, Arunaditya Deshmukh, Inderjeet Kaur, Surabhi Dabral, Niharika Singh, Zille Anam, Ayushi Chaurasiya, Shikha Kaushik, Pradeep Dahiya, Md. Kalamuddin, Jitendra Kumar Thakur, Asif Mohmmed, Anand Ranganathan, Pawan Malhotra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60e8d5ad67374fa7af1433ab34a1e56f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60e8d5ad67374fa7af1433ab34a1e56f
record_format	dspace
spelling	oai:doaj.org-article:60e8d5ad67374fa7af1433ab34a1e56f2021-12-02T17:01:17ZHuman Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum10.1038/s41467-017-01638-62041-1723https://doaj.org/article/60e8d5ad67374fa7af1433ab34a1e56f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01638-6https://doaj.org/toc/2041-1723Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.Prem PrakashMohammad ZeeshanEkta SainiAzhar MuneerSachin KhuranaBishwanath Kumar ChourasiaArunaditya DeshmukhInderjeet KaurSurabhi DabralNiharika SinghZille AnamAyushi ChaurasiyaShikha KaushikPradeep DahiyaMd. KalamuddinJitendra Kumar ThakurAsif MohmmedAnand RanganathanPawan MalhotraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prem Prakash Mohammad Zeeshan Ekta Saini Azhar Muneer Sachin Khurana Bishwanath Kumar Chourasia Arunaditya Deshmukh Inderjeet Kaur Surabhi Dabral Niharika Singh Zille Anam Ayushi Chaurasiya Shikha Kaushik Pradeep Dahiya Md. Kalamuddin Jitendra Kumar Thakur Asif Mohmmed Anand Ranganathan Pawan Malhotra Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
description	Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.
format	article
author	Prem Prakash Mohammad Zeeshan Ekta Saini Azhar Muneer Sachin Khurana Bishwanath Kumar Chourasia Arunaditya Deshmukh Inderjeet Kaur Surabhi Dabral Niharika Singh Zille Anam Ayushi Chaurasiya Shikha Kaushik Pradeep Dahiya Md. Kalamuddin Jitendra Kumar Thakur Asif Mohmmed Anand Ranganathan Pawan Malhotra
author_facet	Prem Prakash Mohammad Zeeshan Ekta Saini Azhar Muneer Sachin Khurana Bishwanath Kumar Chourasia Arunaditya Deshmukh Inderjeet Kaur Surabhi Dabral Niharika Singh Zille Anam Ayushi Chaurasiya Shikha Kaushik Pradeep Dahiya Md. Kalamuddin Jitendra Kumar Thakur Asif Mohmmed Anand Ranganathan Pawan Malhotra
author_sort	Prem Prakash
title	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
title_short	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
title_full	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
title_fullStr	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
title_full_unstemmed	Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
title_sort	human cyclophilin b forms part of a multi-protein complex during erythrocyte invasion by plasmodium falciparum
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60e8d5ad67374fa7af1433ab34a1e56f
work_keys_str_mv	AT premprakash humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT mohammadzeeshan humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT ektasaini humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT azharmuneer humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT sachinkhurana humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT bishwanathkumarchourasia humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT arunadityadeshmukh humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT inderjeetkaur humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT surabhidabral humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT niharikasingh humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT zilleanam humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT ayushichaurasiya humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT shikhakaushik humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT pradeepdahiya humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT mdkalamuddin humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT jitendrakumarthakur humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT asifmohmmed humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT anandranganathan humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum AT pawanmalhotra humancyclophilinbformspartofamultiproteincomplexduringerythrocyteinvasionbyplasmodiumfalciparum
_version_	1718382209777270784

Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum

Ejemplares similares