Role of microRNAs in Obesity-Related Kidney Disease

Obesity is a major global health problem and is associated with a significant risk of renal function decline. Obesity-related nephropathy, as one of the complications of obesity, is characterized by a structural and functional damage of the kidney and represents one of the important contributors to...

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Autores principales:	Maite Caus, Àuria Eritja, Milica Bozic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNAs obesity kidney hyperlipidemia lipotoxicity obesity-related kidney disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/60e9ab3496894cd3a6d260a9f1c6433b
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spelling	oai:doaj.org-article:60e9ab3496894cd3a6d260a9f1c6433b2021-11-11T16:53:40ZRole of microRNAs in Obesity-Related Kidney Disease10.3390/ijms2221114161422-00671661-6596https://doaj.org/article/60e9ab3496894cd3a6d260a9f1c6433b2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11416https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Obesity is a major global health problem and is associated with a significant risk of renal function decline. Obesity-related nephropathy, as one of the complications of obesity, is characterized by a structural and functional damage of the kidney and represents one of the important contributors to the morbidity and mortality worldwide. Despite increasing data linking hyperlipidemia and lipotoxicity to kidney injury, the apprehension of molecular mechanisms leading to a development of kidney damage is scarce. MicroRNAs (miRNAs) are endogenously produced small noncoding RNA molecules with an important function in post-transcriptional regulation of gene expression. miRNAs have been demonstrated to be important regulators of a vast array of physiological and pathological processes in many organs, kidney being one of them. In this review, we present an overview of miRNAs, focusing on their functional role in the pathogenesis of obesity-associated renal pathologies. We explain novel findings regarding miRNA-mediated signaling in obesity-related nephropathies and highlight advantages and future perspectives of the therapeutic application of miRNAs in renal diseases.Maite CausÀuria EritjaMilica BozicMDPI AGarticlemicroRNAsobesitykidneyhyperlipidemialipotoxicityobesity-related kidney diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11416, p 11416 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNAs obesity kidney hyperlipidemia lipotoxicity obesity-related kidney disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	microRNAs obesity kidney hyperlipidemia lipotoxicity obesity-related kidney disease Biology (General) QH301-705.5 Chemistry QD1-999 Maite Caus Àuria Eritja Milica Bozic Role of microRNAs in Obesity-Related Kidney Disease
description	Obesity is a major global health problem and is associated with a significant risk of renal function decline. Obesity-related nephropathy, as one of the complications of obesity, is characterized by a structural and functional damage of the kidney and represents one of the important contributors to the morbidity and mortality worldwide. Despite increasing data linking hyperlipidemia and lipotoxicity to kidney injury, the apprehension of molecular mechanisms leading to a development of kidney damage is scarce. MicroRNAs (miRNAs) are endogenously produced small noncoding RNA molecules with an important function in post-transcriptional regulation of gene expression. miRNAs have been demonstrated to be important regulators of a vast array of physiological and pathological processes in many organs, kidney being one of them. In this review, we present an overview of miRNAs, focusing on their functional role in the pathogenesis of obesity-associated renal pathologies. We explain novel findings regarding miRNA-mediated signaling in obesity-related nephropathies and highlight advantages and future perspectives of the therapeutic application of miRNAs in renal diseases.
format	article
author	Maite Caus Àuria Eritja Milica Bozic
author_facet	Maite Caus Àuria Eritja Milica Bozic
author_sort	Maite Caus
title	Role of microRNAs in Obesity-Related Kidney Disease
title_short	Role of microRNAs in Obesity-Related Kidney Disease
title_full	Role of microRNAs in Obesity-Related Kidney Disease
title_fullStr	Role of microRNAs in Obesity-Related Kidney Disease
title_full_unstemmed	Role of microRNAs in Obesity-Related Kidney Disease
title_sort	role of micrornas in obesity-related kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60e9ab3496894cd3a6d260a9f1c6433b
work_keys_str_mv	AT maitecaus roleofmicrornasinobesityrelatedkidneydisease AT auriaeritja roleofmicrornasinobesityrelatedkidneydisease AT milicabozic roleofmicrornasinobesityrelatedkidneydisease
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Role of microRNAs in Obesity-Related Kidney Disease

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