Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Regnase-1 is known to mediate post-trasncriptional regulatory activity through degradation of target mRNAs. Here, the authors show that Regnase-1 regulates self-renewal of haematopoietic stem and progenitor cells through modulation of the stability of Gata2 and Tal1 mRNA.

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Autores principales:	Hiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60ea1588085a4c4e8b2d1deefdae9a0c
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spelling	oai:doaj.org-article:60ea1588085a4c4e8b2d1deefdae9a0c2021-12-02T15:35:13ZRegnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis10.1038/s41467-019-09028-w2041-1723https://doaj.org/article/60ea1588085a4c4e8b2d1deefdae9a0c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09028-whttps://doaj.org/toc/2041-1723Regnase-1 is known to mediate post-trasncriptional regulatory activity through degradation of target mRNAs. Here, the authors show that Regnase-1 regulates self-renewal of haematopoietic stem and progenitor cells through modulation of the stability of Gata2 and Tal1 mRNA.Hiroyasu KidoyaFumitaka MuramatsuTeppei ShimamuraWeizhen JiaTakashi SatohYumiko HayashiHisamichi NaitoYuya KunisakiFumio AraiMasahide SekiYutaka SuzukiTsuyoshi OsawaShizuo AkiraNobuyuki TakakuraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroyasu Kidoya Fumitaka Muramatsu Teppei Shimamura Weizhen Jia Takashi Satoh Yumiko Hayashi Hisamichi Naito Yuya Kunisaki Fumio Arai Masahide Seki Yutaka Suzuki Tsuyoshi Osawa Shizuo Akira Nobuyuki Takakura Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
description	Regnase-1 is known to mediate post-trasncriptional regulatory activity through degradation of target mRNAs. Here, the authors show that Regnase-1 regulates self-renewal of haematopoietic stem and progenitor cells through modulation of the stability of Gata2 and Tal1 mRNA.
format	article
author	Hiroyasu Kidoya Fumitaka Muramatsu Teppei Shimamura Weizhen Jia Takashi Satoh Yumiko Hayashi Hisamichi Naito Yuya Kunisaki Fumio Arai Masahide Seki Yutaka Suzuki Tsuyoshi Osawa Shizuo Akira Nobuyuki Takakura
author_facet	Hiroyasu Kidoya Fumitaka Muramatsu Teppei Shimamura Weizhen Jia Takashi Satoh Yumiko Hayashi Hisamichi Naito Yuya Kunisaki Fumio Arai Masahide Seki Yutaka Suzuki Tsuyoshi Osawa Shizuo Akira Nobuyuki Takakura
author_sort	Hiroyasu Kidoya
title	Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
title_short	Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
title_full	Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
title_fullStr	Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
title_full_unstemmed	Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
title_sort	regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/60ea1588085a4c4e8b2d1deefdae9a0c
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Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

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