Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study

Objective: The intent was to analyse the association of periodontitis with the development of rheumatoid arthritis (RA) using a representative population-based cohort and longitudinal matched-cohort design. Methods: Participants were 40 years of age or older and had not been diagnosed with RA betwee...

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Autores principales:	Yoon Young Choi, Kyeong Hee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Epidemiology Matched case-control studies Periodontitis Proportional hazard models Rheumatoid arthritis Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/60ed7ed4eaa94c2d910e8620190a54b3
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spelling	oai:doaj.org-article:60ed7ed4eaa94c2d910e8620190a54b32021-11-24T04:21:32ZPeriodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study0020-653910.1016/j.identj.2021.01.006https://doaj.org/article/60ed7ed4eaa94c2d910e8620190a54b32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S002065392100006Xhttps://doaj.org/toc/0020-6539Objective: The intent was to analyse the association of periodontitis with the development of rheumatoid arthritis (RA) using a representative population-based cohort and longitudinal matched-cohort design. Methods: Participants were 40 years of age or older and had not been diagnosed with RA between 2002 and 2006. Among the participants, those who were newly diagnosed with periodontitis between 2004 and 2006 (excluding cases that had already been diagnosed with periodontitis between 2002 and 2003) were allotted to the periodontitis group. Among the participants, those who had never been diagnosed with periodontitis between 2002 and 2006 formed the control group, matched by sex, age, and household income at a 1:1 ratio. From 2007 to 2018, the 2 groups (n = 691,506) were followed to monitor the development of RA. The t-test and χ2 test compared the general characteristics and health-related variables of both groups. The Kaplan-Meier method with a log-rank test was conducted to compare the incidence of RA in both groups. The hazard ratio (HR) and adjusted hazard ratio (aHR) were calculated using a Cox proportional hazard regression analysis to evaluate the risk of subsequent RA. Results: Univariate analysis revealed that the periodontitis group was more likely to develop RA than the control group (hazard ratio 1.10), and multivariate analysis also revealed a higher incidence risk of RA (adjusted hazard ratio 1.09) in the periodontitis group. Conclusions: Our findings demonstrate that periodontitis is associated with an increased risk of developing RA.Yoon Young ChoiKyeong Hee LeeElsevierarticleEpidemiologyMatched case-control studiesPeriodontitisProportional hazard modelsRheumatoid arthritisDentistryRK1-715ENInternational Dental Journal, Vol 71, Iss 6, Pp 516-521 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epidemiology Matched case-control studies Periodontitis Proportional hazard models Rheumatoid arthritis Dentistry RK1-715
spellingShingle	Epidemiology Matched case-control studies Periodontitis Proportional hazard models Rheumatoid arthritis Dentistry RK1-715 Yoon Young Choi Kyeong Hee Lee Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
description	Objective: The intent was to analyse the association of periodontitis with the development of rheumatoid arthritis (RA) using a representative population-based cohort and longitudinal matched-cohort design. Methods: Participants were 40 years of age or older and had not been diagnosed with RA between 2002 and 2006. Among the participants, those who were newly diagnosed with periodontitis between 2004 and 2006 (excluding cases that had already been diagnosed with periodontitis between 2002 and 2003) were allotted to the periodontitis group. Among the participants, those who had never been diagnosed with periodontitis between 2002 and 2006 formed the control group, matched by sex, age, and household income at a 1:1 ratio. From 2007 to 2018, the 2 groups (n = 691,506) were followed to monitor the development of RA. The t-test and χ2 test compared the general characteristics and health-related variables of both groups. The Kaplan-Meier method with a log-rank test was conducted to compare the incidence of RA in both groups. The hazard ratio (HR) and adjusted hazard ratio (aHR) were calculated using a Cox proportional hazard regression analysis to evaluate the risk of subsequent RA. Results: Univariate analysis revealed that the periodontitis group was more likely to develop RA than the control group (hazard ratio 1.10), and multivariate analysis also revealed a higher incidence risk of RA (adjusted hazard ratio 1.09) in the periodontitis group. Conclusions: Our findings demonstrate that periodontitis is associated with an increased risk of developing RA.
format	article
author	Yoon Young Choi Kyeong Hee Lee
author_facet	Yoon Young Choi Kyeong Hee Lee
author_sort	Yoon Young Choi
title	Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
title_short	Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
title_full	Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
title_fullStr	Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
title_full_unstemmed	Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study
title_sort	periodontitis as a risk factor for rheumatoid arthritis: a matched-cohort study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/60ed7ed4eaa94c2d910e8620190a54b3
work_keys_str_mv	AT yoonyoungchoi periodontitisasariskfactorforrheumatoidarthritisamatchedcohortstudy AT kyeongheelee periodontitisasariskfactorforrheumatoidarthritisamatchedcohortstudy
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Periodontitis as a Risk Factor for Rheumatoid Arthritis: a Matched-Cohort Study

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