Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage

Lead (Pb) poisoning and the induced potential of the lesion is a global concern with harmful effects on multiple body systems, particularly the liver system. In this study, we have investigated the efficacy of aqueous-alcoholic extract of parsley leaves (PAE), which is a component of flavonoids that...

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Autores principales:	Fatemeh BASTAMPOOR, Seyed Ebrahim HOSSEINI, Mehrdad SHARIATI, Mokhtar MOKHTARI
Formato:	article
Lenguaje:	EN
Publicado:	University of Kafkas 2021
Materias:	lead stress liver apoptosis parsley leaves Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/60ee7051db234a83b4ef466b16ddaf80
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spelling	oai:doaj.org-article:60ee7051db234a83b4ef466b16ddaf802021-12-05T08:11:53ZExposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage10.9775/kvfd.2021.261631300-60451309-2251https://doaj.org/article/60ee7051db234a83b4ef466b16ddaf802021-11-01T00:00:00Zhttp://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2847.pdfhttps://doaj.org/toc/1300-6045https://doaj.org/toc/1309-2251Lead (Pb) poisoning and the induced potential of the lesion is a global concern with harmful effects on multiple body systems, particularly the liver system. In this study, we have investigated the efficacy of aqueous-alcoholic extract of parsley leaves (PAE), which is a component of flavonoids that could play an important role in the antioxidant property, in preventing liver Pb-damages. For this, sixty adult male rats were randomly divided into six groups in a factorial arrangement: control; receiving oral gavage for 21 days with 2 mL water; 500 ppm Pb; 100 and 200 mg/kg PAE in combination form with Pb, and 200 mg/kg PAE. Liver enzymes and oxidative stress indexes were computed for liver stress, in blood serum. Apoptosis levels were assessed in the evaluation of liver gene expression. Data indicated that Pb reduced liver weight and feed intake. The results showed that Pb significantly increased the liver enzymes contents in the blood serum in the comparison vehicle group. Furthermore, the MDA contents of the Pb group rats were significantly more than that of the vehicle group. Likewise, T-AOC and the activities of CAT and SOD were significantly reduced. Meanwhile, Pb administration induced liver apoptosis-related genes by upregulating Bax and TNF-α genes and downregulating the Bcl-2 gene of animals. At the same time, administration of PAE significantly improved liver oxidative and apoptosis changes. Thus, this study provides a novel mechanistic approach concerning Pb-induced toxicity, due to PAE antioxidant activity.Fatemeh BASTAMPOORSeyed Ebrahim HOSSEINI Mehrdad SHARIATIMokhtar MOKHTARIUniversity of Kafkasarticleleadstressliverapoptosisparsley leavesVeterinary medicineSF600-1100ENKafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 6, Pp 717-723 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lead stress liver apoptosis parsley leaves Veterinary medicine SF600-1100
spellingShingle	lead stress liver apoptosis parsley leaves Veterinary medicine SF600-1100 Fatemeh BASTAMPOOR Seyed Ebrahim HOSSEINI Mehrdad SHARIATI Mokhtar MOKHTARI Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
description	Lead (Pb) poisoning and the induced potential of the lesion is a global concern with harmful effects on multiple body systems, particularly the liver system. In this study, we have investigated the efficacy of aqueous-alcoholic extract of parsley leaves (PAE), which is a component of flavonoids that could play an important role in the antioxidant property, in preventing liver Pb-damages. For this, sixty adult male rats were randomly divided into six groups in a factorial arrangement: control; receiving oral gavage for 21 days with 2 mL water; 500 ppm Pb; 100 and 200 mg/kg PAE in combination form with Pb, and 200 mg/kg PAE. Liver enzymes and oxidative stress indexes were computed for liver stress, in blood serum. Apoptosis levels were assessed in the evaluation of liver gene expression. Data indicated that Pb reduced liver weight and feed intake. The results showed that Pb significantly increased the liver enzymes contents in the blood serum in the comparison vehicle group. Furthermore, the MDA contents of the Pb group rats were significantly more than that of the vehicle group. Likewise, T-AOC and the activities of CAT and SOD were significantly reduced. Meanwhile, Pb administration induced liver apoptosis-related genes by upregulating Bax and TNF-α genes and downregulating the Bcl-2 gene of animals. At the same time, administration of PAE significantly improved liver oxidative and apoptosis changes. Thus, this study provides a novel mechanistic approach concerning Pb-induced toxicity, due to PAE antioxidant activity.
format	article
author	Fatemeh BASTAMPOOR Seyed Ebrahim HOSSEINI Mehrdad SHARIATI Mokhtar MOKHTARI
author_facet	Fatemeh BASTAMPOOR Seyed Ebrahim HOSSEINI Mehrdad SHARIATI Mokhtar MOKHTARI
author_sort	Fatemeh BASTAMPOOR
title	Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
title_short	Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
title_full	Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
title_fullStr	Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
title_full_unstemmed	Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage
title_sort	exposure to aqueous-alcoholic extract of parsley leaves (petroselinum crispum) in lead-treated rats alleviate liver damage
publisher	University of Kafkas
publishDate	2021
url	https://doaj.org/article/60ee7051db234a83b4ef466b16ddaf80
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Exposure to Aqueous-Alcoholic Extract of Parsley Leaves (Petroselinum crispum) in Lead-Treated Rats Alleviate Liver Damage

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