A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity

CDC25 phosphatases are important cell cycle regulators. Here, the authors show that the LIM domain-containing proteins (for example, FHL1) induce inhibitory CDC25 phosphorylation resulting in radioresistance and that a specific peptide can increase tumour radiosensitivity by increasing CDC25 activit...

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Autores principales:	Xiaojie Xu, Zhongyi Fan, Chaoyang Liang, Ling Li, Lili Wang, Yingchun Liang, Jun Wu, Shaohong Chang, Zhifeng Yan, Zhaohui Lv, Jing Fu, Yang Liu, Shuai Jin, Tao Wang, Tian Hong, Yishan Dong, Lihua Ding, Long Cheng, Rui Liu, Shenbo Fu, Shunchang Jiao, Qinong Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60f058f0e1434c64bd9c0e75019f2b90
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spelling	oai:doaj.org-article:60f058f0e1434c64bd9c0e75019f2b902021-12-02T14:40:35ZA signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity10.1038/ncomms140592041-1723https://doaj.org/article/60f058f0e1434c64bd9c0e75019f2b902017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14059https://doaj.org/toc/2041-1723CDC25 phosphatases are important cell cycle regulators. Here, the authors show that the LIM domain-containing proteins (for example, FHL1) induce inhibitory CDC25 phosphorylation resulting in radioresistance and that a specific peptide can increase tumour radiosensitivity by increasing CDC25 activity.Xiaojie XuZhongyi FanChaoyang LiangLing LiLili WangYingchun LiangJun WuShaohong ChangZhifeng YanZhaohui LvJing FuYang LiuShuai JinTao WangTian HongYishan DongLihua DingLong ChengRui LiuShenbo FuShunchang JiaoQinong YeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaojie Xu Zhongyi Fan Chaoyang Liang Ling Li Lili Wang Yingchun Liang Jun Wu Shaohong Chang Zhifeng Yan Zhaohui Lv Jing Fu Yang Liu Shuai Jin Tao Wang Tian Hong Yishan Dong Lihua Ding Long Cheng Rui Liu Shenbo Fu Shunchang Jiao Qinong Ye A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
description	CDC25 phosphatases are important cell cycle regulators. Here, the authors show that the LIM domain-containing proteins (for example, FHL1) induce inhibitory CDC25 phosphorylation resulting in radioresistance and that a specific peptide can increase tumour radiosensitivity by increasing CDC25 activity.
format	article
author	Xiaojie Xu Zhongyi Fan Chaoyang Liang Ling Li Lili Wang Yingchun Liang Jun Wu Shaohong Chang Zhifeng Yan Zhaohui Lv Jing Fu Yang Liu Shuai Jin Tao Wang Tian Hong Yishan Dong Lihua Ding Long Cheng Rui Liu Shenbo Fu Shunchang Jiao Qinong Ye
author_facet	Xiaojie Xu Zhongyi Fan Chaoyang Liang Ling Li Lili Wang Yingchun Liang Jun Wu Shaohong Chang Zhifeng Yan Zhaohui Lv Jing Fu Yang Liu Shuai Jin Tao Wang Tian Hong Yishan Dong Lihua Ding Long Cheng Rui Liu Shenbo Fu Shunchang Jiao Qinong Ye
author_sort	Xiaojie Xu
title	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
title_short	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
title_full	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
title_fullStr	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
title_full_unstemmed	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
title_sort	signature motif in lim proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60f058f0e1434c64bd9c0e75019f2b90
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A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity

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