Binding of Alphaherpesvirus Glycoprotein H to Surface α<sub>4</sub>β<sub>1</sub>-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane

Binding of Alphaherpesvirus Glycoprotein H to Surface α<sub>4</sub>β<sub>1</sub>-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane

ABSTRACT Intracellular signaling connected to integrin activation is known to induce cytoplasmic Ca2+ release, which in turn mediates a number of downstream signals. The cellular entry pathways of two closely related alphaherpesviruses, equine herpesviruses 1 and 4 (EHV-1 and EHV-4), are differentia...

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Autores principales: Walid Azab, Andrea Gramatica, Andreas Herrmann, Nikolaus Osterrieder
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/60f1405a7c364c92ba6b1642166a5e6e
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