Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents

Inhibition, one of the building blocks of executive function, is the ability to focus one’s attention despite interference from external stimuli. It undergoes substantial development during adolescence and may be susceptible to adverse impacts of prenatal exposure to chemical mixtures, yet few studi...

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Autores principales:	Anna V. Oppenheimer, David C. Bellinger, Brent A. Coull, Marc G. Weisskopf, Michele Zemplenyi, Susan A. Korrick
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prenatal exposures chemical mixtures organochlorines metals inhibition executive function Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/60f2ea3dc03640dcbfb83bcc12787ee2
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spelling	oai:doaj.org-article:60f2ea3dc03640dcbfb83bcc12787ee22021-11-25T19:08:20ZPrenatal Exposure to Chemical Mixtures and Inhibition among Adolescents10.3390/toxics91103112305-6304https://doaj.org/article/60f2ea3dc03640dcbfb83bcc12787ee22021-11-01T00:00:00Zhttps://www.mdpi.com/2305-6304/9/11/311https://doaj.org/toc/2305-6304Inhibition, one of the building blocks of executive function, is the ability to focus one’s attention despite interference from external stimuli. It undergoes substantial development during adolescence and may be susceptible to adverse impacts of prenatal exposure to chemical mixtures, yet few studies have explored this association. The New Bedford Cohort (NBC) is a birth cohort of residents living near the New Bedford Harbor Superfund site in Massachusetts. Among adolescents from the NBC, we investigated the association of biomarkers of prenatal exposure to organochlorines (DDE, HCB, PCBs) and metals (Pb, Mn) with inhibition, assessed with the Delis–Kaplan Executive Function System Design Fluency (non-verbal task) and Color–Word Interference (verbal task) subtests. An exploratory mixtures analysis using Bayesian kernel machine regression (BKMR) informed a traditional multivariable regression approach. NBC adolescents are diverse with 29% non-white and 31% in a low-income household at birth. Cord serum organochlorine concentrations and cord blood metals concentrations were generally similar to other birth cohorts. In BKMR models, we observed a suggestive adverse association of the chemical mixture with Color–Word Interference but not Design Fluency. In covariate-adjusted linear regression models including all five chemical exposure measures, a doubling of cord blood Mn was associated with poorer Color–Word Interference completion time scaled scores (difference = −0.74; 95% CI: −1.34, −0.14). This study provided evidence of an adverse joint association between prenatal exposure to a five-chemical mixture and verbal inhibition in adolescence with exposure to Mn potentially driving this overall association.Anna V. OppenheimerDavid C. BellingerBrent A. CoullMarc G. WeisskopfMichele ZemplenyiSusan A. KorrickMDPI AGarticleprenatal exposureschemical mixturesorganochlorinesmetalsinhibitionexecutive functionChemical technologyTP1-1185ENToxics, Vol 9, Iss 311, p 311 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prenatal exposures chemical mixtures organochlorines metals inhibition executive function Chemical technology TP1-1185
spellingShingle	prenatal exposures chemical mixtures organochlorines metals inhibition executive function Chemical technology TP1-1185 Anna V. Oppenheimer David C. Bellinger Brent A. Coull Marc G. Weisskopf Michele Zemplenyi Susan A. Korrick Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
description	Inhibition, one of the building blocks of executive function, is the ability to focus one’s attention despite interference from external stimuli. It undergoes substantial development during adolescence and may be susceptible to adverse impacts of prenatal exposure to chemical mixtures, yet few studies have explored this association. The New Bedford Cohort (NBC) is a birth cohort of residents living near the New Bedford Harbor Superfund site in Massachusetts. Among adolescents from the NBC, we investigated the association of biomarkers of prenatal exposure to organochlorines (DDE, HCB, PCBs) and metals (Pb, Mn) with inhibition, assessed with the Delis–Kaplan Executive Function System Design Fluency (non-verbal task) and Color–Word Interference (verbal task) subtests. An exploratory mixtures analysis using Bayesian kernel machine regression (BKMR) informed a traditional multivariable regression approach. NBC adolescents are diverse with 29% non-white and 31% in a low-income household at birth. Cord serum organochlorine concentrations and cord blood metals concentrations were generally similar to other birth cohorts. In BKMR models, we observed a suggestive adverse association of the chemical mixture with Color–Word Interference but not Design Fluency. In covariate-adjusted linear regression models including all five chemical exposure measures, a doubling of cord blood Mn was associated with poorer Color–Word Interference completion time scaled scores (difference = −0.74; 95% CI: −1.34, −0.14). This study provided evidence of an adverse joint association between prenatal exposure to a five-chemical mixture and verbal inhibition in adolescence with exposure to Mn potentially driving this overall association.
format	article
author	Anna V. Oppenheimer David C. Bellinger Brent A. Coull Marc G. Weisskopf Michele Zemplenyi Susan A. Korrick
author_facet	Anna V. Oppenheimer David C. Bellinger Brent A. Coull Marc G. Weisskopf Michele Zemplenyi Susan A. Korrick
author_sort	Anna V. Oppenheimer
title	Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
title_short	Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
title_full	Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
title_fullStr	Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
title_full_unstemmed	Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents
title_sort	prenatal exposure to chemical mixtures and inhibition among adolescents
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60f2ea3dc03640dcbfb83bcc12787ee2
work_keys_str_mv	AT annavoppenheimer prenatalexposuretochemicalmixturesandinhibitionamongadolescents AT davidcbellinger prenatalexposuretochemicalmixturesandinhibitionamongadolescents AT brentacoull prenatalexposuretochemicalmixturesandinhibitionamongadolescents AT marcgweisskopf prenatalexposuretochemicalmixturesandinhibitionamongadolescents AT michelezemplenyi prenatalexposuretochemicalmixturesandinhibitionamongadolescents AT susanakorrick prenatalexposuretochemicalmixturesandinhibitionamongadolescents
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Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents

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