Model-driven generation of artificial yeast promoters
A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.
Guardado en:
Autores principales: | , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:60f4d5679ca14b2e8e6f8ec1bb4c67b7 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:60f4d5679ca14b2e8e6f8ec1bb4c67b72021-12-02T15:39:22ZModel-driven generation of artificial yeast promoters10.1038/s41467-020-15977-42041-1723https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b72020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15977-4https://doaj.org/toc/2041-1723A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.Benjamin J. KotopkaChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Benjamin J. Kotopka Christina D. Smolke Model-driven generation of artificial yeast promoters |
description |
A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters. |
format |
article |
author |
Benjamin J. Kotopka Christina D. Smolke |
author_facet |
Benjamin J. Kotopka Christina D. Smolke |
author_sort |
Benjamin J. Kotopka |
title |
Model-driven generation of artificial yeast promoters |
title_short |
Model-driven generation of artificial yeast promoters |
title_full |
Model-driven generation of artificial yeast promoters |
title_fullStr |
Model-driven generation of artificial yeast promoters |
title_full_unstemmed |
Model-driven generation of artificial yeast promoters |
title_sort |
model-driven generation of artificial yeast promoters |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7 |
work_keys_str_mv |
AT benjaminjkotopka modeldrivengenerationofartificialyeastpromoters AT christinadsmolke modeldrivengenerationofartificialyeastpromoters |
_version_ |
1718385933873577984 |