Model-driven generation of artificial yeast promoters

A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.

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Autores principales: Benjamin J. Kotopka, Christina D. Smolke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7
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spelling oai:doaj.org-article:60f4d5679ca14b2e8e6f8ec1bb4c67b72021-12-02T15:39:22ZModel-driven generation of artificial yeast promoters10.1038/s41467-020-15977-42041-1723https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b72020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15977-4https://doaj.org/toc/2041-1723A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.Benjamin J. KotopkaChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benjamin J. Kotopka
Christina D. Smolke
Model-driven generation of artificial yeast promoters
description A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.
format article
author Benjamin J. Kotopka
Christina D. Smolke
author_facet Benjamin J. Kotopka
Christina D. Smolke
author_sort Benjamin J. Kotopka
title Model-driven generation of artificial yeast promoters
title_short Model-driven generation of artificial yeast promoters
title_full Model-driven generation of artificial yeast promoters
title_fullStr Model-driven generation of artificial yeast promoters
title_full_unstemmed Model-driven generation of artificial yeast promoters
title_sort model-driven generation of artificial yeast promoters
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7
work_keys_str_mv AT benjaminjkotopka modeldrivengenerationofartificialyeastpromoters
AT christinadsmolke modeldrivengenerationofartificialyeastpromoters
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