AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY

Abstract. Role of cytokines in autoimmune reactions in Graves–Basedow disease (GBD) is undisputable. It has been shown, that dynamic alterations in serum Th1 and Th2 marker cytokines are dependent on disease stage. At initial phase of autoimmune thyrotoxicosis, the maximal values were shown for IL-1...

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Autores principales:	E. V. Markelova, V. V. Lazanovich
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines autoantibodies autoimmune thyrotoxicosis il-1α il-8 ifnγ il-10 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/60f5631df6b5497e816f999cc11e5835
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spelling	oai:doaj.org-article:60f5631df6b5497e816f999cc11e58352021-11-18T08:03:38ZAUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY1563-06252313-741X10.15789/1563-0625-2008-2-3-245-250https://doaj.org/article/60f5631df6b5497e816f999cc11e58352014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/162https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Role of cytokines in autoimmune reactions in Graves–Basedow disease (GBD) is undisputable. It has been shown, that dynamic alterations in serum Th1 and Th2 marker cytokines are dependent on disease stage. At initial phase of autoimmune thyrotoxicosis, the maximal values were shown for IL-1α, IL-8, IFNγ and IL-10. A direct correlation is proven between the degree of disease severity, and the levels of proinflammatory (IL-1α, IL-8, IFNγ), as well as anti-inflammatory cytokines (IL-10), like as with production of antibodies against thyroid receptors. During conventional treatment with standard doses of thiamazol, the levels of cytokines are significantly decreased. These data extend our knowledge on pathogenetic mechanisms of the disorder. Moreover, they allow of developing an algorithm for assessment of therapeutic efficiency and probability of relapses in autoimmune thyrotoxicosis. (Med. Immunol., 2008, vol. 10, N 2-3, pp 245-250).E. V. MarkelovaV. V. LazanovichSPb RAACIarticlecytokinesautoantibodiesautoimmune thyrotoxicosisil-1αil-8ifnγil-10Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 245-250 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines autoantibodies autoimmune thyrotoxicosis il-1α il-8 ifnγ il-10 Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines autoantibodies autoimmune thyrotoxicosis il-1α il-8 ifnγ il-10 Immunologic diseases. Allergy RC581-607 E. V. Markelova V. V. Lazanovich AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
description	Abstract. Role of cytokines in autoimmune reactions in Graves–Basedow disease (GBD) is undisputable. It has been shown, that dynamic alterations in serum Th1 and Th2 marker cytokines are dependent on disease stage. At initial phase of autoimmune thyrotoxicosis, the maximal values were shown for IL-1α, IL-8, IFNγ and IL-10. A direct correlation is proven between the degree of disease severity, and the levels of proinflammatory (IL-1α, IL-8, IFNγ), as well as anti-inflammatory cytokines (IL-10), like as with production of antibodies against thyroid receptors. During conventional treatment with standard doses of thiamazol, the levels of cytokines are significantly decreased. These data extend our knowledge on pathogenetic mechanisms of the disorder. Moreover, they allow of developing an algorithm for assessment of therapeutic efficiency and probability of relapses in autoimmune thyrotoxicosis. (Med. Immunol., 2008, vol. 10, N 2-3, pp 245-250).
format	article
author	E. V. Markelova V. V. Lazanovich
author_facet	E. V. Markelova V. V. Lazanovich
author_sort	E. V. Markelova
title	AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
title_short	AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
title_full	AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
title_fullStr	AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
title_full_unstemmed	AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY
title_sort	autoantibodies and cytokine profile in patients with graves–basedow disease and their dynamics during thionamide therapy
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/60f5631df6b5497e816f999cc11e5835
work_keys_str_mv	AT evmarkelova autoantibodiesandcytokineprofileinpatientswithgravesbasedowdiseaseandtheirdynamicsduringthionamidetherapy AT vvlazanovich autoantibodiesandcytokineprofileinpatientswithgravesbasedowdiseaseandtheirdynamicsduringthionamidetherapy
_version_	1718422545891328000

AUTOANTIBODIES AND CYTOKINE PROFILE IN PATIENTS WITH GRAVES–BASEDOW DISEASE AND THEIR DYNAMICS DURING THIONAMIDE THERAPY

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