Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions

Cell membrane interface is mostly studied using synthetic bilayers and reconstituted cell membranes. Here the authors present a new cell fixation method in which the cytoskeleton is replaced by a synthetic hydrogel polymer network assembled inside the cell, thereby preserving the fluid membrane prop...

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Autores principales: Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yuan-I Chen, Yu-Han Liu, Zih-Syun Fang, Jui-Yi Chen, Wei-ya Chen, No-No Lee, Hui-Wen Chen, Che-Ming J. Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/60f70ab26b30453c9a34acb65a4bb0ab
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Sumario:Cell membrane interface is mostly studied using synthetic bilayers and reconstituted cell membranes. Here the authors present a new cell fixation method in which the cytoskeleton is replaced by a synthetic hydrogel polymer network assembled inside the cell, thereby preserving the fluid membrane properties after cell death.