Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke
Abstract The detection of underlying atrial fibrillation (AF) has become increasingly possible by insertable cardiac monitoring (ICM). During hospitalization for cryptogenic stroke, factors related to the early and late development of AF have not been studied. CHALLENGE ESUS/CS is a multicenter regi...
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Nature Portfolio
2021
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oai:doaj.org-article:60f70f22365943d5b372a428024b23a22021-12-02T14:23:05ZDifferent aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke10.1038/s41598-021-86620-52045-2322https://doaj.org/article/60f70f22365943d5b372a428024b23a22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86620-5https://doaj.org/toc/2045-2322Abstract The detection of underlying atrial fibrillation (AF) has become increasingly possible by insertable cardiac monitoring (ICM). During hospitalization for cryptogenic stroke, factors related to the early and late development of AF have not been studied. CHALLENGE ESUS/CS is a multicenter registry of cryptogenic stroke patients undergoing transesophageal echocardiography. Twelve-lead electrocardiogram, continuous cardiac monitoring, and 24-h Holter electrocardiogram were all used for the detection of AF. Early and late detection of AF was determined with an allocation ratio of 1:1 among patients with AF. A total of 677 patients (68.7 ± 12.8 years; 455 men) were enrolled, and 64 patients developed AF during hospitalization. Four days after admission was identified as the approximate median day to classify early and late phases to detect AF: ≤ 4 days, 37 patients; > 4 days, 27 patients. Multiple logistic regression analysis showed that spontaneous echo contrast (SEC) (OR 5.91; 95% CI 2.19–15.97; p < 0.001) was associated with AF ≤ 4 days, whereas a large infarction > 3 cm in diameter (OR 3.28; 95% CI 1.35–7.97; p = 0.009) was associated with AF > 4 days. SEC and large infarctions were important predictors of in-hospital AF detection, particularly in the early and late stages, respectively; thus, they could serve as indications for recommending ICM.Ryosuke DoijiriYuji UenoMuneaki KikunoTakahiro ShimizuYohei TateishiAyako KurikiHidehiro TakekawaYoshiaki ShimadaKodai KanemaruYuki KamiyaEriko YamaguchiMasatoshi KogaMasafumi IharaAkira TsujinoKoichi HirataYasuhiro HasegawaTakahiko KikuchiNobutaka HattoriTakao UrabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Ryosuke Doijiri Yuji Ueno Muneaki Kikuno Takahiro Shimizu Yohei Tateishi Ayako Kuriki Hidehiro Takekawa Yoshiaki Shimada Kodai Kanemaru Yuki Kamiya Eriko Yamaguchi Masatoshi Koga Masafumi Ihara Akira Tsujino Koichi Hirata Yasuhiro Hasegawa Takahiko Kikuchi Nobutaka Hattori Takao Urabe Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| description |
Abstract The detection of underlying atrial fibrillation (AF) has become increasingly possible by insertable cardiac monitoring (ICM). During hospitalization for cryptogenic stroke, factors related to the early and late development of AF have not been studied. CHALLENGE ESUS/CS is a multicenter registry of cryptogenic stroke patients undergoing transesophageal echocardiography. Twelve-lead electrocardiogram, continuous cardiac monitoring, and 24-h Holter electrocardiogram were all used for the detection of AF. Early and late detection of AF was determined with an allocation ratio of 1:1 among patients with AF. A total of 677 patients (68.7 ± 12.8 years; 455 men) were enrolled, and 64 patients developed AF during hospitalization. Four days after admission was identified as the approximate median day to classify early and late phases to detect AF: ≤ 4 days, 37 patients; > 4 days, 27 patients. Multiple logistic regression analysis showed that spontaneous echo contrast (SEC) (OR 5.91; 95% CI 2.19–15.97; p < 0.001) was associated with AF ≤ 4 days, whereas a large infarction > 3 cm in diameter (OR 3.28; 95% CI 1.35–7.97; p = 0.009) was associated with AF > 4 days. SEC and large infarctions were important predictors of in-hospital AF detection, particularly in the early and late stages, respectively; thus, they could serve as indications for recommending ICM. |
| format |
article |
| author |
Ryosuke Doijiri Yuji Ueno Muneaki Kikuno Takahiro Shimizu Yohei Tateishi Ayako Kuriki Hidehiro Takekawa Yoshiaki Shimada Kodai Kanemaru Yuki Kamiya Eriko Yamaguchi Masatoshi Koga Masafumi Ihara Akira Tsujino Koichi Hirata Yasuhiro Hasegawa Takahiko Kikuchi Nobutaka Hattori Takao Urabe |
| author_facet |
Ryosuke Doijiri Yuji Ueno Muneaki Kikuno Takahiro Shimizu Yohei Tateishi Ayako Kuriki Hidehiro Takekawa Yoshiaki Shimada Kodai Kanemaru Yuki Kamiya Eriko Yamaguchi Masatoshi Koga Masafumi Ihara Akira Tsujino Koichi Hirata Yasuhiro Hasegawa Takahiko Kikuchi Nobutaka Hattori Takao Urabe |
| author_sort |
Ryosuke Doijiri |
| title |
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| title_short |
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| title_full |
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| title_fullStr |
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| title_full_unstemmed |
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| title_sort |
different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/60f70f22365943d5b372a428024b23a2 |
| work_keys_str_mv |
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