Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)

Patama Bhurayanontachai, Mansing Ratanasukon, Pichai JirarattanasopaRetina Unit, Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandPurpose: To determine the pattern of electroretinographic change after an intravitreal ranibizumab (Lucentis&...

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Autores principales:	Bhurayanontachai P, Ratanasukon M, Jirarattanasopa P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/60f85c34c60b486f80df8414407c1411
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spelling	oai:doaj.org-article:60f85c34c60b486f80df8414407c14112021-12-02T04:12:00ZElectrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)1177-54671177-5483https://doaj.org/article/60f85c34c60b486f80df8414407c14112011-05-01T00:00:00Zhttp://www.dovepress.com/electrophysiologic-changes-after-intravitreal-ranibizumab-injection-fo-a7361https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Patama Bhurayanontachai, Mansing Ratanasukon, Pichai JirarattanasopaRetina Unit, Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandPurpose: To determine the pattern of electroretinographic change after an intravitreal ranibizumab (Lucentis&reg;) injection for the treatment of choroidal neovascular membrane (CNVM).Patients and methods: A prospective interventional case series of patients treated by intravitreal ranibizumab injection. Best corrected visual acuity, optical coherence tomography (OCT), and multifocal electroretinography (mfERG) were assessed prior to treatment, and 2 weeks, 1 and 3 months after treatment. Primary outcome was the functional change in amplitude and implicit time by mfERG and secondary outcome was the structural change in macular thickness by optical coherence tomography (OCT).Results: Twenty-six eyes from 25 consecutive patients were enrolled. At 3 months after treatment, the mean visual acuity (VA) improved from 1.06 to 0.84 logMAR (P = 0.034) and the mean macular thickness decreased from 389.7 to 264.4 microns (P = 0.003). The mean implicit time of the central zone showed an improvement at 3 months after treatment when compared with the response at baseline (P = 0.024) and at 1 month (P = 0.013) but the mean amplitude showed no significant change. In subgroup analysis, the eyes with initial visual acuity (VA)&nbsp;&ge; 20/200 had a significant improvement in mean implicit time of the peripheral zone at 2 weeks after treatment (P = 0.028). The OCT revealed a significant decrease (P&nbsp;&lt; 0.003) in macular thickness at 1 and 3 months postoperatively.Conclusion: The mean implicit time of the central zone improved significantly at 3 months after treatment, whereas the mean amplitude showed no significant change. The macular thickness decreased significantly after the treatment, while VA improved to a lesser extent.Keywords: choroidal neovascular membrane (CNVM), intravitreal injection, multifocal electroretinography (mfERG), optical coherence tomography (OCT), ranibizumabBhurayanontachai PRatanasukon MJirarattanasopa PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 567-572 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Bhurayanontachai P Ratanasukon M Jirarattanasopa P Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
description	Patama Bhurayanontachai, Mansing Ratanasukon, Pichai JirarattanasopaRetina Unit, Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandPurpose: To determine the pattern of electroretinographic change after an intravitreal ranibizumab (Lucentis&reg;) injection for the treatment of choroidal neovascular membrane (CNVM).Patients and methods: A prospective interventional case series of patients treated by intravitreal ranibizumab injection. Best corrected visual acuity, optical coherence tomography (OCT), and multifocal electroretinography (mfERG) were assessed prior to treatment, and 2 weeks, 1 and 3 months after treatment. Primary outcome was the functional change in amplitude and implicit time by mfERG and secondary outcome was the structural change in macular thickness by optical coherence tomography (OCT).Results: Twenty-six eyes from 25 consecutive patients were enrolled. At 3 months after treatment, the mean visual acuity (VA) improved from 1.06 to 0.84 logMAR (P = 0.034) and the mean macular thickness decreased from 389.7 to 264.4 microns (P = 0.003). The mean implicit time of the central zone showed an improvement at 3 months after treatment when compared with the response at baseline (P = 0.024) and at 1 month (P = 0.013) but the mean amplitude showed no significant change. In subgroup analysis, the eyes with initial visual acuity (VA)&nbsp;&ge; 20/200 had a significant improvement in mean implicit time of the peripheral zone at 2 weeks after treatment (P = 0.028). The OCT revealed a significant decrease (P&nbsp;&lt; 0.003) in macular thickness at 1 and 3 months postoperatively.Conclusion: The mean implicit time of the central zone improved significantly at 3 months after treatment, whereas the mean amplitude showed no significant change. The macular thickness decreased significantly after the treatment, while VA improved to a lesser extent.Keywords: choroidal neovascular membrane (CNVM), intravitreal injection, multifocal electroretinography (mfERG), optical coherence tomography (OCT), ranibizumab
format	article
author	Bhurayanontachai P Ratanasukon M Jirarattanasopa P
author_facet	Bhurayanontachai P Ratanasukon M Jirarattanasopa P
author_sort	Bhurayanontachai P
title	Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
title_short	Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
title_full	Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
title_fullStr	Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
title_full_unstemmed	Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)
title_sort	electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (cnvm)
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/60f85c34c60b486f80df8414407c1411
work_keys_str_mv	AT bhurayanontachaip electrophysiologicchangesafterintravitrealranibizumabinjectionforthetreatmentofchoroidalneovascularmembranecnvm AT ratanasukonm electrophysiologicchangesafterintravitrealranibizumabinjectionforthetreatmentofchoroidalneovascularmembranecnvm AT jirarattanasopap electrophysiologicchangesafterintravitrealranibizumabinjectionforthetreatmentofchoroidalneovascularmembranecnvm
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Electrophysiologic changes after intravitreal ranibizumab injection for the treatment of choroidal neovascular membrane (CNVM)

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