Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review

Lymphoepithelioma-like carcinoma is a rare type of tumor that is histologically identical to lymphoepithelial carcinoma of the nasopharynx. Lymphoepithelioma-like carcinomas (LELCs) are closely associated with viral infections. Human papillomavirus (HPV)-associated LELCs have been reported in a vari...

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Autores principales:	Weiwei Weng, Weiqi Sheng, Lei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	human papillomavirus lymphoepithelioma-like carcinoma anal canal immune microenvironment case report Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/60feeda381c64bf6a0ba177cd411b4df
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spelling	oai:doaj.org-article:60feeda381c64bf6a0ba177cd411b4df2021-11-19T14:30:50ZHuman Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review2296-858X10.3389/fmed.2021.766960https://doaj.org/article/60feeda381c64bf6a0ba177cd411b4df2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.766960/fullhttps://doaj.org/toc/2296-858XLymphoepithelioma-like carcinoma is a rare type of tumor that is histologically identical to lymphoepithelial carcinoma of the nasopharynx. Lymphoepithelioma-like carcinomas (LELCs) are closely associated with viral infections. Human papillomavirus (HPV)-associated LELCs have been reported in a variety of anatomic sites. We reported an extremely rare case of a 25-year-old woman with LELC derived from the anal canal, which is the second case reported at this site. The tumor was diffusely positive for p16 staining, and was correlated with high-risk HPV-16; Epstein-Barr virus-encoded small RNA was negative; PD-L1 positivity and abundant CD8+ T cell infiltration were observed, indicating a “hot” immune microenvironment. In reporting this case, we highlight the potential for misdiagnosis and suggested an association of HPV infection with LELC in the anal canal.Weiwei WengWeiwei WengWeiwei WengWeiqi ShengWeiqi ShengWeiqi ShengLei WangLei WangLei WangFrontiers Media S.A.articlehuman papillomaviruslymphoepithelioma-like carcinomaanal canalimmune microenvironmentcase reportMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human papillomavirus lymphoepithelioma-like carcinoma anal canal immune microenvironment case report Medicine (General) R5-920
spellingShingle	human papillomavirus lymphoepithelioma-like carcinoma anal canal immune microenvironment case report Medicine (General) R5-920 Weiwei Weng Weiwei Weng Weiwei Weng Weiqi Sheng Weiqi Sheng Weiqi Sheng Lei Wang Lei Wang Lei Wang Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
description	Lymphoepithelioma-like carcinoma is a rare type of tumor that is histologically identical to lymphoepithelial carcinoma of the nasopharynx. Lymphoepithelioma-like carcinomas (LELCs) are closely associated with viral infections. Human papillomavirus (HPV)-associated LELCs have been reported in a variety of anatomic sites. We reported an extremely rare case of a 25-year-old woman with LELC derived from the anal canal, which is the second case reported at this site. The tumor was diffusely positive for p16 staining, and was correlated with high-risk HPV-16; Epstein-Barr virus-encoded small RNA was negative; PD-L1 positivity and abundant CD8+ T cell infiltration were observed, indicating a “hot” immune microenvironment. In reporting this case, we highlight the potential for misdiagnosis and suggested an association of HPV infection with LELC in the anal canal.
format	article
author	Weiwei Weng Weiwei Weng Weiwei Weng Weiqi Sheng Weiqi Sheng Weiqi Sheng Lei Wang Lei Wang Lei Wang
author_facet	Weiwei Weng Weiwei Weng Weiwei Weng Weiqi Sheng Weiqi Sheng Weiqi Sheng Lei Wang Lei Wang Lei Wang
author_sort	Weiwei Weng
title	Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
title_short	Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
title_full	Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
title_fullStr	Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
title_full_unstemmed	Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review
title_sort	human papillomavirus-associated lymphoepithelioma-like carcinoma of the anal canal: a case report and literature review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/60feeda381c64bf6a0ba177cd411b4df
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Human Papillomavirus-Associated Lymphoepithelioma-Like Carcinoma of the Anal Canal: A Case Report and Literature Review

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