Sex-specific transcriptional and proteomic signatures in schizophrenia

Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozyg...

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Autores principales:	Jari Tiihonen, Marja Koskuvi, Markus Storvik, Ida Hyötyläinen, Yanyan Gao, Katja A. Puttonen, Raisa Giniatullina, Ekaterina Poguzhelskaya, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Lesley Cheng, Andrew F. Hill, Markku Lähteenvuo, Jussi Tohka, Rashid Giniatullin, Šárka Lehtonen, Jari Koistinaho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61016b2a66ea4dce8f5588786287831c
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spelling	oai:doaj.org-article:61016b2a66ea4dce8f5588786287831c2021-12-02T17:01:48ZSex-specific transcriptional and proteomic signatures in schizophrenia10.1038/s41467-019-11797-32041-1723https://doaj.org/article/61016b2a66ea4dce8f5588786287831c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11797-3https://doaj.org/toc/2041-1723Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozygotic twin pairs, and demonstrate that although sexes share many of the final common pathways, the underlying primary pathophysiology of SCZ differs between males and females.Jari TiihonenMarja KoskuviMarkus StorvikIda HyötyläinenYanyan GaoKatja A. PuttonenRaisa GiniatullinaEkaterina PoguzhelskayaIlkka OjansuuOlli VaurioTyrone D. CannonJouko LönnqvistSebastian ThermanJaana SuvisaariJaakko KaprioLesley ChengAndrew F. HillMarkku LähteenvuoJussi TohkaRashid GiniatullinŠárka LehtonenJari KoistinahoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jari Tiihonen Marja Koskuvi Markus Storvik Ida Hyötyläinen Yanyan Gao Katja A. Puttonen Raisa Giniatullina Ekaterina Poguzhelskaya Ilkka Ojansuu Olli Vaurio Tyrone D. Cannon Jouko Lönnqvist Sebastian Therman Jaana Suvisaari Jaakko Kaprio Lesley Cheng Andrew F. Hill Markku Lähteenvuo Jussi Tohka Rashid Giniatullin Šárka Lehtonen Jari Koistinaho Sex-specific transcriptional and proteomic signatures in schizophrenia
description	Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozygotic twin pairs, and demonstrate that although sexes share many of the final common pathways, the underlying primary pathophysiology of SCZ differs between males and females.
format	article
author	Jari Tiihonen Marja Koskuvi Markus Storvik Ida Hyötyläinen Yanyan Gao Katja A. Puttonen Raisa Giniatullina Ekaterina Poguzhelskaya Ilkka Ojansuu Olli Vaurio Tyrone D. Cannon Jouko Lönnqvist Sebastian Therman Jaana Suvisaari Jaakko Kaprio Lesley Cheng Andrew F. Hill Markku Lähteenvuo Jussi Tohka Rashid Giniatullin Šárka Lehtonen Jari Koistinaho
author_facet	Jari Tiihonen Marja Koskuvi Markus Storvik Ida Hyötyläinen Yanyan Gao Katja A. Puttonen Raisa Giniatullina Ekaterina Poguzhelskaya Ilkka Ojansuu Olli Vaurio Tyrone D. Cannon Jouko Lönnqvist Sebastian Therman Jaana Suvisaari Jaakko Kaprio Lesley Cheng Andrew F. Hill Markku Lähteenvuo Jussi Tohka Rashid Giniatullin Šárka Lehtonen Jari Koistinaho
author_sort	Jari Tiihonen
title	Sex-specific transcriptional and proteomic signatures in schizophrenia
title_short	Sex-specific transcriptional and proteomic signatures in schizophrenia
title_full	Sex-specific transcriptional and proteomic signatures in schizophrenia
title_fullStr	Sex-specific transcriptional and proteomic signatures in schizophrenia
title_full_unstemmed	Sex-specific transcriptional and proteomic signatures in schizophrenia
title_sort	sex-specific transcriptional and proteomic signatures in schizophrenia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61016b2a66ea4dce8f5588786287831c
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Sex-specific transcriptional and proteomic signatures in schizophrenia

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