PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antivir...

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Autores principales: Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi, Yayoi Kimura, Mayuko Nishi, Hirokazu Kimura, Hironori Sato, Hisashi Hirano, Tomohiko Tamura, Hirofumi Akari, Tomoyuki Miura, Akio Adachi, Tatsuya Sawasaki, Naoki Yamamoto, Akihide Ryo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/6102736bfc484ca3b0b10f8fb9a53fa8
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Sumario:The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.

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