PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antivir...

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Autores principales:	Kei Miyakawa, Satoko Matsunaga, Masaru Yokoyama, Masako Nomaguchi, Yayoi Kimura, Mayuko Nishi, Hirokazu Kimura, Hironori Sato, Hisashi Hirano, Tomohiko Tamura, Hirofumi Akari, Tomoyuki Miura, Akio Adachi, Tatsuya Sawasaki, Naoki Yamamoto, Akihide Ryo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6102736bfc484ca3b0b10f8fb9a53fa8
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spelling	oai:doaj.org-article:6102736bfc484ca3b0b10f8fb9a53fa82021-12-02T16:57:23ZPIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation10.1038/s41467-019-09867-72041-1723https://doaj.org/article/6102736bfc484ca3b0b10f8fb9a53fa82019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09867-7https://doaj.org/toc/2041-1723The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.Kei MiyakawaSatoko MatsunagaMasaru YokoyamaMasako NomaguchiYayoi KimuraMayuko NishiHirokazu KimuraHironori SatoHisashi HiranoTomohiko TamuraHirofumi AkariTomoyuki MiuraAkio AdachiTatsuya SawasakiNaoki YamamotoAkihide RyoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kei Miyakawa Satoko Matsunaga Masaru Yokoyama Masako Nomaguchi Yayoi Kimura Mayuko Nishi Hirokazu Kimura Hironori Sato Hisashi Hirano Tomohiko Tamura Hirofumi Akari Tomoyuki Miura Akio Adachi Tatsuya Sawasaki Naoki Yamamoto Akihide Ryo PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
description	The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.
format	article
author	Kei Miyakawa Satoko Matsunaga Masaru Yokoyama Masako Nomaguchi Yayoi Kimura Mayuko Nishi Hirokazu Kimura Hironori Sato Hisashi Hirano Tomohiko Tamura Hirofumi Akari Tomoyuki Miura Akio Adachi Tatsuya Sawasaki Naoki Yamamoto Akihide Ryo
author_facet	Kei Miyakawa Satoko Matsunaga Masaru Yokoyama Masako Nomaguchi Yayoi Kimura Mayuko Nishi Hirokazu Kimura Hironori Sato Hisashi Hirano Tomohiko Tamura Hirofumi Akari Tomoyuki Miura Akio Adachi Tatsuya Sawasaki Naoki Yamamoto Akihide Ryo
author_sort	Kei Miyakawa
title	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
title_short	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
title_full	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
title_fullStr	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
title_full_unstemmed	PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
title_sort	pim kinases facilitate lentiviral evasion from samhd1 restriction via vpx phosphorylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6102736bfc484ca3b0b10f8fb9a53fa8
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PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

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