High-potency ligands for DREADD imaging and activation in rodents and monkeys

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.

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Autores principales:	Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
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spelling	oai:doaj.org-article:61041765c18b4742add3c9f64f5d75802021-12-02T17:01:33ZHigh-potency ligands for DREADD imaging and activation in rodents and monkeys10.1038/s41467-019-12236-z2041-1723https://doaj.org/article/61041765c18b4742add3c9f64f5d75802019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12236-zhttps://doaj.org/toc/2041-1723Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.Jordi BonaventuraMark A. G. EldridgeFeng HuJuan L. GomezMarta Sanchez-SotoAra M. AbramyanSherry LamMatthew A. BoehmChristina RuizMitchell R. FarrellAndrea MorenoIslam Mustafa Galal FaressNiels AndersenJohn Y. LinRuin MoaddelPatrick J. MorrisLei ShiDavid R. SibleyStephen V. MahlerSadegh NabaviMartin G. PomperAntonello BonciAndrew G. HortiBarry J. RichmondMichael MichaelidesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordi Bonaventura Mark A. G. Eldridge Feng Hu Juan L. Gomez Marta Sanchez-Soto Ara M. Abramyan Sherry Lam Matthew A. Boehm Christina Ruiz Mitchell R. Farrell Andrea Moreno Islam Mustafa Galal Faress Niels Andersen John Y. Lin Ruin Moaddel Patrick J. Morris Lei Shi David R. Sibley Stephen V. Mahler Sadegh Nabavi Martin G. Pomper Antonello Bonci Andrew G. Horti Barry J. Richmond Michael Michaelides High-potency ligands for DREADD imaging and activation in rodents and monkeys
description	Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.
format	article
author	Jordi Bonaventura Mark A. G. Eldridge Feng Hu Juan L. Gomez Marta Sanchez-Soto Ara M. Abramyan Sherry Lam Matthew A. Boehm Christina Ruiz Mitchell R. Farrell Andrea Moreno Islam Mustafa Galal Faress Niels Andersen John Y. Lin Ruin Moaddel Patrick J. Morris Lei Shi David R. Sibley Stephen V. Mahler Sadegh Nabavi Martin G. Pomper Antonello Bonci Andrew G. Horti Barry J. Richmond Michael Michaelides
author_facet	Jordi Bonaventura Mark A. G. Eldridge Feng Hu Juan L. Gomez Marta Sanchez-Soto Ara M. Abramyan Sherry Lam Matthew A. Boehm Christina Ruiz Mitchell R. Farrell Andrea Moreno Islam Mustafa Galal Faress Niels Andersen John Y. Lin Ruin Moaddel Patrick J. Morris Lei Shi David R. Sibley Stephen V. Mahler Sadegh Nabavi Martin G. Pomper Antonello Bonci Andrew G. Horti Barry J. Richmond Michael Michaelides
author_sort	Jordi Bonaventura
title	High-potency ligands for DREADD imaging and activation in rodents and monkeys
title_short	High-potency ligands for DREADD imaging and activation in rodents and monkeys
title_full	High-potency ligands for DREADD imaging and activation in rodents and monkeys
title_fullStr	High-potency ligands for DREADD imaging and activation in rodents and monkeys
title_full_unstemmed	High-potency ligands for DREADD imaging and activation in rodents and monkeys
title_sort	high-potency ligands for dreadd imaging and activation in rodents and monkeys
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
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High-potency ligands for DREADD imaging and activation in rodents and monkeys

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