Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex

The piriform cortex (PCx) is essential for learning of odor information. The current view postulates that odor learning in the PCx is mainly due to plasticity in intracortical (IC) synapses, while odor information from the olfactory bulb carried via the lateral olfactory tract (LOT) is ‘hardwired.’...

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Autores principales:	Amit Kumar, Edi Barkai, Jackie Schiller
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	piriform cortex dendrites NMDA-spikes LTP odor processing optogenetics Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6106302782364648b68f9090ec9d4002
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spelling	oai:doaj.org-article:6106302782364648b68f9090ec9d40022021-11-24T12:27:39ZPlasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex10.7554/eLife.703832050-084Xe70383https://doaj.org/article/6106302782364648b68f9090ec9d40022021-10-01T00:00:00Zhttps://elifesciences.org/articles/70383https://doaj.org/toc/2050-084XThe piriform cortex (PCx) is essential for learning of odor information. The current view postulates that odor learning in the PCx is mainly due to plasticity in intracortical (IC) synapses, while odor information from the olfactory bulb carried via the lateral olfactory tract (LOT) is ‘hardwired.’ Here, we revisit this notion by studying location- and pathway-dependent plasticity rules. We find that in contrast to the prevailing view, synaptic and optogenetically activated LOT synapses undergo strong and robust long-term potentiation (LTP) mediated by only a few local NMDA-spikes delivered at theta frequency, while global spike timing-dependent plasticity (STDP) protocols failed to induce LTP in these distal synapses. In contrast, IC synapses in apical and basal dendrites undergo plasticity with both NMDA-spikes and STDP protocols but to a smaller extent compared with LOT synapses. These results are consistent with a self-potentiating mechanism of odor information via NMDA-spikes that can form branch-specific memory traces of odors that can further associate with contextual IC information via STDP mechanisms to provide cognitive and emotional value to odors.Amit KumarEdi BarkaiJackie SchillereLife Sciences Publications Ltdarticlepiriform cortexdendritesNMDA-spikesLTPodor processingoptogeneticsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	piriform cortex dendrites NMDA-spikes LTP odor processing optogenetics Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	piriform cortex dendrites NMDA-spikes LTP odor processing optogenetics Medicine R Science Q Biology (General) QH301-705.5 Amit Kumar Edi Barkai Jackie Schiller Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
description	The piriform cortex (PCx) is essential for learning of odor information. The current view postulates that odor learning in the PCx is mainly due to plasticity in intracortical (IC) synapses, while odor information from the olfactory bulb carried via the lateral olfactory tract (LOT) is ‘hardwired.’ Here, we revisit this notion by studying location- and pathway-dependent plasticity rules. We find that in contrast to the prevailing view, synaptic and optogenetically activated LOT synapses undergo strong and robust long-term potentiation (LTP) mediated by only a few local NMDA-spikes delivered at theta frequency, while global spike timing-dependent plasticity (STDP) protocols failed to induce LTP in these distal synapses. In contrast, IC synapses in apical and basal dendrites undergo plasticity with both NMDA-spikes and STDP protocols but to a smaller extent compared with LOT synapses. These results are consistent with a self-potentiating mechanism of odor information via NMDA-spikes that can form branch-specific memory traces of odors that can further associate with contextual IC information via STDP mechanisms to provide cognitive and emotional value to odors.
format	article
author	Amit Kumar Edi Barkai Jackie Schiller
author_facet	Amit Kumar Edi Barkai Jackie Schiller
author_sort	Amit Kumar
title	Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
title_short	Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
title_full	Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
title_fullStr	Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
title_full_unstemmed	Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex
title_sort	plasticity of olfactory bulb inputs mediated by dendritic nmda-spikes in rodent piriform cortex
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/6106302782364648b68f9090ec9d4002
work_keys_str_mv	AT amitkumar plasticityofolfactorybulbinputsmediatedbydendriticnmdaspikesinrodentpiriformcortex AT edibarkai plasticityofolfactorybulbinputsmediatedbydendriticnmdaspikesinrodentpiriformcortex AT jackieschiller plasticityofolfactorybulbinputsmediatedbydendriticnmdaspikesinrodentpiriformcortex
_version_	1718415049188442112

Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex

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