Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer

Abstract Extraprostatic extension (EPE) is a factor in determining pT3a stage in prostate cancer. However, the only distinction in EPE is whether it is focal or non-focal, causing diagnostic and prognostic ambiguity. We substaged pT3a malignancies using classification of EPE to improve personalized...

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Autores principales:	Cheol Keun Park, Yeon Seung Chung, Young Deuk Choi, Won Sik Ham, Won Sik Jang, Nam Hoon Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61067fa94d164ad2bd766ddab380d183
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spelling	oai:doaj.org-article:61067fa94d164ad2bd766ddab380d1832021-12-02T15:22:57ZRevisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer10.1038/s41598-021-93340-32045-2322https://doaj.org/article/61067fa94d164ad2bd766ddab380d1832021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93340-3https://doaj.org/toc/2045-2322Abstract Extraprostatic extension (EPE) is a factor in determining pT3a stage in prostate cancer. However, the only distinction in EPE is whether it is focal or non-focal, causing diagnostic and prognostic ambiguity. We substaged pT3a malignancies using classification of EPE to improve personalized prognostication. We evaluated 465 radical prostatectomy specimens with a digital image analyzer by measuring the number, radial distance and two-dimensional square area of the EPE. The most significant cut-off value was proposed as an algorithm for the pT3a substaging system to predict biochemical recurrence (BCR). A combination of the radial distance and the number of EPEs predicted BCR the most effectively. The optimal cut-off criteria were 0.75 mm and 2 mm in radial distance and multifocal EPE (hazard ratio: 2.526, C-index 0.656). The pT3a was subdivided into pT3a1, < 0.75 mm and any number of EPEs; pT3a2, 0.75–2 mm and one EPE; and pT3a3, > 2 mm and any number of EPEs or 0.75–2 mm and ≥ 2 EPEs. This combined tier was highly significant in the prediction of BCR-free survival. The combination of radial distance and number of EPEs could be used to subdivide pT3a prostate cancer and may aid in the prediction of BCR.Cheol Keun ParkYeon Seung ChungYoung Deuk ChoiWon Sik HamWon Sik JangNam Hoon ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheol Keun Park Yeon Seung Chung Young Deuk Choi Won Sik Ham Won Sik Jang Nam Hoon Cho Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
description	Abstract Extraprostatic extension (EPE) is a factor in determining pT3a stage in prostate cancer. However, the only distinction in EPE is whether it is focal or non-focal, causing diagnostic and prognostic ambiguity. We substaged pT3a malignancies using classification of EPE to improve personalized prognostication. We evaluated 465 radical prostatectomy specimens with a digital image analyzer by measuring the number, radial distance and two-dimensional square area of the EPE. The most significant cut-off value was proposed as an algorithm for the pT3a substaging system to predict biochemical recurrence (BCR). A combination of the radial distance and the number of EPEs predicted BCR the most effectively. The optimal cut-off criteria were 0.75 mm and 2 mm in radial distance and multifocal EPE (hazard ratio: 2.526, C-index 0.656). The pT3a was subdivided into pT3a1, < 0.75 mm and any number of EPEs; pT3a2, 0.75–2 mm and one EPE; and pT3a3, > 2 mm and any number of EPEs or 0.75–2 mm and ≥ 2 EPEs. This combined tier was highly significant in the prediction of BCR-free survival. The combination of radial distance and number of EPEs could be used to subdivide pT3a prostate cancer and may aid in the prediction of BCR.
format	article
author	Cheol Keun Park Yeon Seung Chung Young Deuk Choi Won Sik Ham Won Sik Jang Nam Hoon Cho
author_facet	Cheol Keun Park Yeon Seung Chung Young Deuk Choi Won Sik Ham Won Sik Jang Nam Hoon Cho
author_sort	Cheol Keun Park
title	Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
title_short	Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
title_full	Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
title_fullStr	Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
title_full_unstemmed	Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer
title_sort	revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pt3a prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61067fa94d164ad2bd766ddab380d183
work_keys_str_mv	AT cheolkeunpark revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer AT yeonseungchung revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer AT youngdeukchoi revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer AT wonsikham revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer AT wonsikjang revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer AT namhooncho revisitingextraprostaticextensionbasedoninvasiondepthandnumberfornewalgorithmforsubstagingofpt3aprostatecancer
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Revisiting extraprostatic extension based on invasion depth and number for new algorithm for substaging of pT3a prostate cancer

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