Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe

Abstract Abdominal aortic aneurysm (AAA) remains a fatal disease. Its development encompasses a complex interplay between hemodynamic stimuli on and changes in the arterial wall. Currently available biomarkers fail to predict the risk of AAA rupture independent of aneurysm size. Therefore, novel bio...

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Autores principales:	Lisa C. Adams, Julia Brangsch, Carolin Reimann, Jan O. Kaufmann, Kristin Nowak, Rebecca Buchholz, Uwe Karst, Rene M. Botnar, Bernd Hamm, Marcus R. Makowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/610a4cd45a534f3e9c8facea371c27ed
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spelling	oai:doaj.org-article:610a4cd45a534f3e9c8facea371c27ed2021-12-02T14:28:22ZNoninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe10.1038/s41598-020-59842-22045-2322https://doaj.org/article/610a4cd45a534f3e9c8facea371c27ed2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59842-2https://doaj.org/toc/2045-2322Abstract Abdominal aortic aneurysm (AAA) remains a fatal disease. Its development encompasses a complex interplay between hemodynamic stimuli on and changes in the arterial wall. Currently available biomarkers fail to predict the risk of AAA rupture independent of aneurysm size. Therefore, novel biomarkers for AAA characterization are needed. In this study, we used a mouse model of AAA to investigate the potential of magnetic resonance imaging (MRI) with an albumin-binding probe to assess changes in vascular permeability at different stages of aneurysm growth. Two imaging studies were performed: a longitudinal study with follow-up and death as endpoint to predict rupture risk and a week-by-week study to characterize AAA development. AAAs, which eventually ruptured, demonstrated a significantly higher in vivo MR signal enhancement from the albumin-binding probe (p = 0.047) and a smaller nonenhancing thrombus area compared to intact AAAs (p = 0.001). The ratio of albumin-binding-probe enhancement of the aneurysm wall to size of nonenhancing-thrombus-area predicted AAA rupture with high sensitivity/specificity (100%/86%). More advanced aneurysms with higher vascular permeability demonstrated an increased uptake of the albumin-binding-probe. These results indicate that MRI with an albumin-binding probe may enable noninvasive assessment of vascular permeability in murine AAAs and prediction of rupture risk.Lisa C. AdamsJulia BrangschCarolin ReimannJan O. KaufmannKristin NowakRebecca BuchholzUwe KarstRene M. BotnarBernd HammMarcus R. MakowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa C. Adams Julia Brangsch Carolin Reimann Jan O. Kaufmann Kristin Nowak Rebecca Buchholz Uwe Karst Rene M. Botnar Bernd Hamm Marcus R. Makowski Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
description	Abstract Abdominal aortic aneurysm (AAA) remains a fatal disease. Its development encompasses a complex interplay between hemodynamic stimuli on and changes in the arterial wall. Currently available biomarkers fail to predict the risk of AAA rupture independent of aneurysm size. Therefore, novel biomarkers for AAA characterization are needed. In this study, we used a mouse model of AAA to investigate the potential of magnetic resonance imaging (MRI) with an albumin-binding probe to assess changes in vascular permeability at different stages of aneurysm growth. Two imaging studies were performed: a longitudinal study with follow-up and death as endpoint to predict rupture risk and a week-by-week study to characterize AAA development. AAAs, which eventually ruptured, demonstrated a significantly higher in vivo MR signal enhancement from the albumin-binding probe (p = 0.047) and a smaller nonenhancing thrombus area compared to intact AAAs (p = 0.001). The ratio of albumin-binding-probe enhancement of the aneurysm wall to size of nonenhancing-thrombus-area predicted AAA rupture with high sensitivity/specificity (100%/86%). More advanced aneurysms with higher vascular permeability demonstrated an increased uptake of the albumin-binding-probe. These results indicate that MRI with an albumin-binding probe may enable noninvasive assessment of vascular permeability in murine AAAs and prediction of rupture risk.
format	article
author	Lisa C. Adams Julia Brangsch Carolin Reimann Jan O. Kaufmann Kristin Nowak Rebecca Buchholz Uwe Karst Rene M. Botnar Bernd Hamm Marcus R. Makowski
author_facet	Lisa C. Adams Julia Brangsch Carolin Reimann Jan O. Kaufmann Kristin Nowak Rebecca Buchholz Uwe Karst Rene M. Botnar Bernd Hamm Marcus R. Makowski
author_sort	Lisa C. Adams
title	Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
title_short	Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
title_full	Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
title_fullStr	Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
title_full_unstemmed	Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
title_sort	noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/610a4cd45a534f3e9c8facea371c27ed
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Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin-binding probe

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