Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis

Objectives This study aimed to investigate the clinicopathological characteristics and prognosis of normotensive and hypertensive IgAN patients with ischemic renal injury. Methods A total of 344 cases of IgAN with ischemic renal injury were included in the study, including 99 normotensive IgAN patie...

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Autores principales:	Yongli Wang, Xutong Wang, Dan Yu, Minhua Xie, Jingjing Ren, Yuze Zhu, Haonan Guo, Songxia Quan, Junjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	blood pressure iga nephropathy ischemic renal injury prognosis renal biopsy Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/610ba952f8ef4a91a7b4ffc76b1d44f4
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spelling	oai:doaj.org-article:610ba952f8ef4a91a7b4ffc76b1d44f42021-11-04T15:00:41ZNormotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis0886-022X1525-604910.1080/0886022X.2021.1994996https://doaj.org/article/610ba952f8ef4a91a7b4ffc76b1d44f42021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/0886022X.2021.1994996https://doaj.org/toc/0886-022Xhttps://doaj.org/toc/1525-6049Objectives This study aimed to investigate the clinicopathological characteristics and prognosis of normotensive and hypertensive IgAN patients with ischemic renal injury. Methods A total of 344 cases of IgAN with ischemic renal injury were included in the study, including 99 normotensive IgAN patients (28.8%) and 245 hypertensive IgAN patients (71.2%). In addition, 467 IgAN patients without ischemic renal injury were included as controls, including 205 normotensive patients and 262 hypertensive patients. Clinicopathological and prognostic data were collected and analyzed. Results Compared with patients without ischemic renal injury, IgAN patients with ischemic renal injury displayed a higher proportion of hypertention, a higher proportion of ischemic glomerulosclerosis, tubular atrophy/interstitial fibrosis and vascular lesions (all p < .05). There was no significant difference in cumulative survival between the normotensive IgAN patients groups (Log-rank χ2 = 0.479; p = .489). Furthermore, ischemic renal injury was not a risk factor for end-point events in normotensive IgAN patients (HR = 1.103; 95% CI: 0.279–4.365; p = .889). There was lower cumulative survival in hypertensive IgAN patients with ischemic renal injury (Log-rank χ2 = 11.352, p = .001). Moreover, ischemic renal injury was a risk factor for end-point events in hypertensive IgAN patients (HR = 1.889; 95% CI: 1.124–3.178; p = .016). Conclusions Ischemic renal injury can occur in normotensive IgAN patients. Although the pathological changes may not affect the long-term prognosis of normotensive IgAN patients, the prognosis for hypertensive IgAN patients remains poor. Therefore, increased attention should be paid to the clinical management of ischemic lesions in hypertensive IgAN patients.Yongli WangXutong WangDan YuMinhua XieJingjing RenYuze ZhuHaonan GuoSongxia QuanJunjun ZhangTaylor & Francis Grouparticleblood pressureiga nephropathyischemic renal injuryprognosisrenal biopsyDiseases of the genitourinary system. UrologyRC870-923ENRenal Failure, Vol 43, Iss 1, Pp 1454-1462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood pressure iga nephropathy ischemic renal injury prognosis renal biopsy Diseases of the genitourinary system. Urology RC870-923
spellingShingle	blood pressure iga nephropathy ischemic renal injury prognosis renal biopsy Diseases of the genitourinary system. Urology RC870-923 Yongli Wang Xutong Wang Dan Yu Minhua Xie Jingjing Ren Yuze Zhu Haonan Guo Songxia Quan Junjun Zhang Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
description	Objectives This study aimed to investigate the clinicopathological characteristics and prognosis of normotensive and hypertensive IgAN patients with ischemic renal injury. Methods A total of 344 cases of IgAN with ischemic renal injury were included in the study, including 99 normotensive IgAN patients (28.8%) and 245 hypertensive IgAN patients (71.2%). In addition, 467 IgAN patients without ischemic renal injury were included as controls, including 205 normotensive patients and 262 hypertensive patients. Clinicopathological and prognostic data were collected and analyzed. Results Compared with patients without ischemic renal injury, IgAN patients with ischemic renal injury displayed a higher proportion of hypertention, a higher proportion of ischemic glomerulosclerosis, tubular atrophy/interstitial fibrosis and vascular lesions (all p < .05). There was no significant difference in cumulative survival between the normotensive IgAN patients groups (Log-rank χ2 = 0.479; p = .489). Furthermore, ischemic renal injury was not a risk factor for end-point events in normotensive IgAN patients (HR = 1.103; 95% CI: 0.279–4.365; p = .889). There was lower cumulative survival in hypertensive IgAN patients with ischemic renal injury (Log-rank χ2 = 11.352, p = .001). Moreover, ischemic renal injury was a risk factor for end-point events in hypertensive IgAN patients (HR = 1.889; 95% CI: 1.124–3.178; p = .016). Conclusions Ischemic renal injury can occur in normotensive IgAN patients. Although the pathological changes may not affect the long-term prognosis of normotensive IgAN patients, the prognosis for hypertensive IgAN patients remains poor. Therefore, increased attention should be paid to the clinical management of ischemic lesions in hypertensive IgAN patients.
format	article
author	Yongli Wang Xutong Wang Dan Yu Minhua Xie Jingjing Ren Yuze Zhu Haonan Guo Songxia Quan Junjun Zhang
author_facet	Yongli Wang Xutong Wang Dan Yu Minhua Xie Jingjing Ren Yuze Zhu Haonan Guo Songxia Quan Junjun Zhang
author_sort	Yongli Wang
title	Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
title_short	Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
title_full	Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
title_fullStr	Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
title_full_unstemmed	Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
title_sort	normotensive and hypertensive immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/610ba952f8ef4a91a7b4ffc76b1d44f4
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Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis

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