The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome

MI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-...

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Autores principales:	Sierra MI, Valdés A, Fernández AF, Torrecillas R, Fraga MF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Nanoparticles nanomaterials DNA methylation histone modification epigenetics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/61120b2e5d374d92961d2d8ae8c603f3
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spelling	oai:doaj.org-article:61120b2e5d374d92961d2d8ae8c603f32021-12-02T01:49:54ZThe effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome1178-2013https://doaj.org/article/61120b2e5d374d92961d2d8ae8c603f32016-11-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-exposure-to-nanoparticles-and-nanomaterials-on-the-mamma-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013MI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain Abstract: Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene–environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health. Keywords: noncoding RNAs, ncRNAs, DNA methylation, histone modification, epigeneticsSierra MIValdés AFernández AFTorrecillas RFraga MFDove Medical PressarticleNanoparticlesnanomaterialsDNA methylationhistone modificationepigeneticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 6297-6306 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanoparticles nanomaterials DNA methylation histone modification epigenetics Medicine (General) R5-920
spellingShingle	Nanoparticles nanomaterials DNA methylation histone modification epigenetics Medicine (General) R5-920 Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
description	MI Sierra,1 A Valdés,2 AF Fernández,1 R Torrecillas,2 MF Fraga2 1Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, 2Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, El Entrego, Spain Abstract: Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects on human health are still largely unknown. Epigenetic modifications are attracting ever more interest as possible underlying molecular mechanisms of gene–environment interactions, highlighting them as potential molecular targets following exposure to nanomaterials and nanoparticles. Interestingly, recent research has identified changes in DNA methylation, histone post-translational modifications, and noncoding RNAs in mammalian cells exposed to nanomaterials and nanoparticles. However, the challenge for the future will be to determine the molecular pathways driving these epigenetic alterations, the possible functional consequences, and the potential effects on health. Keywords: noncoding RNAs, ncRNAs, DNA methylation, histone modification, epigenetics
format	article
author	Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF
author_facet	Sierra MI Valdés A Fernández AF Torrecillas R Fraga MF
author_sort	Sierra MI
title	The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
title_short	The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
title_full	The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
title_fullStr	The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
title_full_unstemmed	The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
title_sort	effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/61120b2e5d374d92961d2d8ae8c603f3
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The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome

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