Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

Abstract Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super-aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here...

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Autores principales:	Eiichi Naito, Tomoyo Morita, Satoshi Hirose, Nodoka Kimura, Hideya Okamoto, Chikako Kamimukai, Minoru Asada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61127feeed8845878a88bc55af3609b6
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spelling	oai:doaj.org-article:61127feeed8845878a88bc55af3609b62021-11-28T12:16:37ZBimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition10.1038/s41598-021-02173-72045-2322https://doaj.org/article/61127feeed8845878a88bc55af3609b62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02173-7https://doaj.org/toc/2045-2322Abstract Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super-aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here, we examined whether bimanual digit exercises, which can train the interhemispheric inhibitory system, improve deteriorated hand/finger dexterity in older adults. Forty-eight healthy, right-handed, older adults (65–78 years old) were divided into two groups, i.e., the bimanual (BM) digit training and right-hand (RH) training groups, and intensive daily training was performed for 2 months. Before and after the training, we evaluated individual right hand/finger dexterity using a peg task, and the individual state of interhemispheric sensorimotor inhibition by analyzing ipsilateral sensorimotor deactivation via functional magnetic resonance imaging when participants experienced a kinesthetic illusory movement of the right-hand without performing any motor tasks. Before training, the degree of reduction/loss of ipsilateral motor-cortical deactivation was associated with dexterity deterioration. After training, the dexterity improved only in the BM group, and the dexterity improvement was correlated with reduction in ipsilateral motor-cortical activity. The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.Eiichi NaitoTomoyo MoritaSatoshi HiroseNodoka KimuraHideya OkamotoChikako KamimukaiMinoru AsadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eiichi Naito Tomoyo Morita Satoshi Hirose Nodoka Kimura Hideya Okamoto Chikako Kamimukai Minoru Asada Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
description	Abstract Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super-aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here, we examined whether bimanual digit exercises, which can train the interhemispheric inhibitory system, improve deteriorated hand/finger dexterity in older adults. Forty-eight healthy, right-handed, older adults (65–78 years old) were divided into two groups, i.e., the bimanual (BM) digit training and right-hand (RH) training groups, and intensive daily training was performed for 2 months. Before and after the training, we evaluated individual right hand/finger dexterity using a peg task, and the individual state of interhemispheric sensorimotor inhibition by analyzing ipsilateral sensorimotor deactivation via functional magnetic resonance imaging when participants experienced a kinesthetic illusory movement of the right-hand without performing any motor tasks. Before training, the degree of reduction/loss of ipsilateral motor-cortical deactivation was associated with dexterity deterioration. After training, the dexterity improved only in the BM group, and the dexterity improvement was correlated with reduction in ipsilateral motor-cortical activity. The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.
format	article
author	Eiichi Naito Tomoyo Morita Satoshi Hirose Nodoka Kimura Hideya Okamoto Chikako Kamimukai Minoru Asada
author_facet	Eiichi Naito Tomoyo Morita Satoshi Hirose Nodoka Kimura Hideya Okamoto Chikako Kamimukai Minoru Asada
author_sort	Eiichi Naito
title	Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
title_short	Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
title_full	Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
title_fullStr	Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
title_full_unstemmed	Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
title_sort	bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61127feeed8845878a88bc55af3609b6
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Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

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