Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer

Abstract Background Hepatitis B virus (HBV) infection has been associated with an increased risk of a few malignancies. However, the prognostic impact of HBV infection remains unclear in cervical cancer. Objective To explore the association between HBV infection and survival outcomes of patients wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoyan Feng, Huaiwu Lu, Yuan Wei, Meimei Guan, Junyi Wang, Changhao Liu, Tianran Shen, Qingsong Chen, Qunxian Rao
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cervical cancer hepatitis B virus (HBV) human papillomavirus (HPV) prognosis surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6115609818324e4bba7bf1623b95a7c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6115609818324e4bba7bf1623b95a7c1
record_format	dspace
spelling	oai:doaj.org-article:6115609818324e4bba7bf1623b95a7c12021-12-01T04:49:14ZPrognostic impact of hepatitis B virus infection in patients with primary cervical cancer2045-763410.1002/cam4.4358https://doaj.org/article/6115609818324e4bba7bf1623b95a7c12021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4358https://doaj.org/toc/2045-7634Abstract Background Hepatitis B virus (HBV) infection has been associated with an increased risk of a few malignancies. However, the prognostic impact of HBV infection remains unclear in cervical cancer. Objective To explore the association between HBV infection and survival outcomes of patients with primary cervical cancer, using overall survival (OS) and disease‐free survival (DFS) as primary endpoints. Methods This analysis was performed retrospectively with newly diagnosed cervical cancer patients admitted to the Department of Gynecologic Oncology at the Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University from June 2013 to October 2019, who were enrolled and followed up. The Kaplan–Meier method and Cox proportional hazard analysis were used to examine the performance of HBV infection in predicting OS and DFS. Results Patients were followed up for a median of 37.17 months (95% CI, 34.69–39.65). Among the 695 patients, 87 (12.5%) were serologically positive for hepatitis B surface antigen (HBsAg), and 276 (39.7%) had a prior history of HBV infection. There was no significant difference between HBsAg‐positive group and HBsAg‐negative patients concerning OS or DFS. Multivariate analysis showed prior HBV infection was an independent favorable prognosticator for OS (HR, 0.335; 95% CI, 0.153–0.0.734; p = 0.006) and DFS (HR, 0.398; 95% CI, 0.208–0.691; p = 0.002). Conclusion We provide the first clinical evidence that suggests prior HBV infection as an independent favorable prognostic factor for patients with primary cervical cancer.Xiaoyan FengHuaiwu LuYuan WeiMeimei GuanJunyi WangChanghao LiuTianran ShenQingsong ChenQunxian RaoWileyarticlecervical cancerhepatitis B virus (HBV)human papillomavirus (HPV)prognosissurgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8310-8319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer hepatitis B virus (HBV) human papillomavirus (HPV) prognosis surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cervical cancer hepatitis B virus (HBV) human papillomavirus (HPV) prognosis surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaoyan Feng Huaiwu Lu Yuan Wei Meimei Guan Junyi Wang Changhao Liu Tianran Shen Qingsong Chen Qunxian Rao Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
description	Abstract Background Hepatitis B virus (HBV) infection has been associated with an increased risk of a few malignancies. However, the prognostic impact of HBV infection remains unclear in cervical cancer. Objective To explore the association between HBV infection and survival outcomes of patients with primary cervical cancer, using overall survival (OS) and disease‐free survival (DFS) as primary endpoints. Methods This analysis was performed retrospectively with newly diagnosed cervical cancer patients admitted to the Department of Gynecologic Oncology at the Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University from June 2013 to October 2019, who were enrolled and followed up. The Kaplan–Meier method and Cox proportional hazard analysis were used to examine the performance of HBV infection in predicting OS and DFS. Results Patients were followed up for a median of 37.17 months (95% CI, 34.69–39.65). Among the 695 patients, 87 (12.5%) were serologically positive for hepatitis B surface antigen (HBsAg), and 276 (39.7%) had a prior history of HBV infection. There was no significant difference between HBsAg‐positive group and HBsAg‐negative patients concerning OS or DFS. Multivariate analysis showed prior HBV infection was an independent favorable prognosticator for OS (HR, 0.335; 95% CI, 0.153–0.0.734; p = 0.006) and DFS (HR, 0.398; 95% CI, 0.208–0.691; p = 0.002). Conclusion We provide the first clinical evidence that suggests prior HBV infection as an independent favorable prognostic factor for patients with primary cervical cancer.
format	article
author	Xiaoyan Feng Huaiwu Lu Yuan Wei Meimei Guan Junyi Wang Changhao Liu Tianran Shen Qingsong Chen Qunxian Rao
author_facet	Xiaoyan Feng Huaiwu Lu Yuan Wei Meimei Guan Junyi Wang Changhao Liu Tianran Shen Qingsong Chen Qunxian Rao
author_sort	Xiaoyan Feng
title	Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
title_short	Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
title_full	Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
title_fullStr	Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
title_full_unstemmed	Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer
title_sort	prognostic impact of hepatitis b virus infection in patients with primary cervical cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/6115609818324e4bba7bf1623b95a7c1
work_keys_str_mv	AT xiaoyanfeng prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT huaiwulu prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT yuanwei prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT meimeiguan prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT junyiwang prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT changhaoliu prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT tianranshen prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT qingsongchen prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer AT qunxianrao prognosticimpactofhepatitisbvirusinfectioninpatientswithprimarycervicalcancer
_version_	1718405725768646656

Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer

Ejemplares similares