BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.

BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.

The EWS/FLI translocation product is the causative oncogene in Ewing sarcoma and acts as an aberrant transcription factor. EWS/FLI dysregulates gene expression during tumorigenesis by abnormally activating or repressing genes. The expression levels of thousands of genes are affected in Ewing sarcoma...

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Autores principales: Elizabeth T Wiles, Bianca Lui-Sargent, Russell Bell, Stephen L Lessnick
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6116bd5bc3a94646a34c47a8b40bb2a9
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