Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion

BACKGROUND AND OBJECTIVE: The use of antioxidants has been considered for the prevention and treatment of ischemic complications, particularly in the brain. Previous study showed a reduction in cell death in brain ischemia before and after treatment with antioxidants. The aim of this study was to in...

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Autores principales:	M Zamani, M Katebi, J Hassanshahi, F Zamani, M Soleimani
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	temporal cortex ischemia-reperfusion mice neuroprotective effect olive oil Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/611922e1342944aab42c2baf9239111b
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spelling	oai:doaj.org-article:611922e1342944aab42c2baf9239111b2021-11-10T08:53:26ZEffect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion1561-41072251-7170https://doaj.org/article/611922e1342944aab42c2baf9239111b2012-09-01T00:00:00Zhttp://jbums.org/article-1-4187-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: The use of antioxidants has been considered for the prevention and treatment of ischemic complications, particularly in the brain. Previous study showed a reduction in cell death in brain ischemia before and after treatment with antioxidants. The aim of this study was to investigate the effect of olive oil on Temporal cortical cell death following ischemia reperfusion injury. METHODS: This study was performed on 21 adult male BALB/c mice (35-40 g). Experimental design includes three groups: intact group (n=7), ischemic control (n=7), treatment groups with olive oil (n=7). The mice treated with olive oil (180 micro liter) as pre- treatment for a week. Then, ischemia in temporal cortex lob induced by common carotid artery occlusion (for 15 minutes) and following the reduction in inflammation (a week), the mice post-treated with olive oil. Nissl staining applied to counting necrotic cells and Tunnel kit was used to quantify apoptotic cell death in temporal cortex lob.FINDINGS: There was a significant increase in cell death in temporal cortex lob in ischemic samples in compared to control group (30-35 cells increased in treatment group compared to ischemia group) (p<0.05). There was a significant decrease in cell death rate in treatment group in compared to ischemia group (50-55 cells decreased in ischemia group compared to control group) (p<0.05).CONCLUSION: Our findings showed that olive oil consumption significantly reduced cell death following ischemia reperfusion injury.M ZamaniM Katebi,J Hassanshahi,F Zamani,M SoleimaniBabol University of Medical Sciencesarticletemporal cortexischemia-reperfusionmiceneuroprotective effectolive oilMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 49-55 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	temporal cortex ischemia-reperfusion mice neuroprotective effect olive oil Medicine R Medicine (General) R5-920
spellingShingle	temporal cortex ischemia-reperfusion mice neuroprotective effect olive oil Medicine R Medicine (General) R5-920 M Zamani M Katebi, J Hassanshahi, F Zamani, M Soleimani Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
description	BACKGROUND AND OBJECTIVE: The use of antioxidants has been considered for the prevention and treatment of ischemic complications, particularly in the brain. Previous study showed a reduction in cell death in brain ischemia before and after treatment with antioxidants. The aim of this study was to investigate the effect of olive oil on Temporal cortical cell death following ischemia reperfusion injury. METHODS: This study was performed on 21 adult male BALB/c mice (35-40 g). Experimental design includes three groups: intact group (n=7), ischemic control (n=7), treatment groups with olive oil (n=7). The mice treated with olive oil (180 micro liter) as pre- treatment for a week. Then, ischemia in temporal cortex lob induced by common carotid artery occlusion (for 15 minutes) and following the reduction in inflammation (a week), the mice post-treated with olive oil. Nissl staining applied to counting necrotic cells and Tunnel kit was used to quantify apoptotic cell death in temporal cortex lob.FINDINGS: There was a significant increase in cell death in temporal cortex lob in ischemic samples in compared to control group (30-35 cells increased in treatment group compared to ischemia group) (p<0.05). There was a significant decrease in cell death rate in treatment group in compared to ischemia group (50-55 cells decreased in ischemia group compared to control group) (p<0.05).CONCLUSION: Our findings showed that olive oil consumption significantly reduced cell death following ischemia reperfusion injury.
format	article
author	M Zamani M Katebi, J Hassanshahi, F Zamani, M Soleimani
author_facet	M Zamani M Katebi, J Hassanshahi, F Zamani, M Soleimani
author_sort	M Zamani
title	Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
title_short	Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
title_full	Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
title_fullStr	Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
title_full_unstemmed	Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion
title_sort	effect of olive oil in brain temporal cortex following ischemia-reperfusion
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/611922e1342944aab42c2baf9239111b
work_keys_str_mv	AT mzamani effectofoliveoilinbraintemporalcortexfollowingischemiareperfusion AT mkatebi effectofoliveoilinbraintemporalcortexfollowingischemiareperfusion AT jhassanshahi effectofoliveoilinbraintemporalcortexfollowingischemiareperfusion AT fzamani effectofoliveoilinbraintemporalcortexfollowingischemiareperfusion AT msoleimani effectofoliveoilinbraintemporalcortexfollowingischemiareperfusion
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Effect of Olive Oil in Brain Temporal Cortex Following Ischemia-Reperfusion

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