Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study

Abstract Diabetes mellitus (DM) is considered an independent risk factor for atrial fibrillation (AF). The excess risk in relation to the presence of proteinuria has not been well elucidated. Our aim was to determine the association between the incidence of AF and proteinuria in diabetic population....

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Autores principales:	Juntae Kim, Pil-Sung Yang, Byoung-Eun Park, Tae Soo Kang, Seong-Hoon Lim, Sungsoo Cho, Su-Yeon Lee, Myung-Yong Lee, Gregory Y. H. Lip, Dongmin Kim, Boyoung Joung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6119dba64bfe46c3b004479d2813dcf1
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spelling	oai:doaj.org-article:6119dba64bfe46c3b004479d2813dcf12021-12-02T15:09:15ZAssociation of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study10.1038/s41598-021-96483-52045-2322https://doaj.org/article/6119dba64bfe46c3b004479d2813dcf12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96483-5https://doaj.org/toc/2045-2322Abstract Diabetes mellitus (DM) is considered an independent risk factor for atrial fibrillation (AF). The excess risk in relation to the presence of proteinuria has not been well elucidated. Our aim was to determine the association between the incidence of AF and proteinuria in diabetic population. A total of 240,499 individuals aged ≥ 60 years from the Korea National Health Insurance Service-Senior cohort from 2004 to 2014 were included. 4.2% of individuals with DM and 3.7% of controls were diagnosed with AF during a median follow-up period of 7.2 years. Amongst controls (participants without proteinuria and DM), DM only, proteinuria only, and DM with proteinuria groups, the crude incidences of AF were 0.58, 0.70, 0.96, 1.24 per 100 person-years respectively. Compared with controls, the weighted risk of AF was increased by 11% (hazard ratio = 1.11, 95% confidence interval = 1.02–1.20, P = .001), 48% (hazard ratio = 1.48, 95% confidence interval = 1.30–1.69, P < .001), and 66% (hazard ratio = 1.66, 95% confidence interval = 1.26–2.18, P < .001) in the DM only, proteinuria only, and DM with proteinuria groups, respectively (P for trend < .001). Degree of proteinuria in diabetic patients was associated with a significantly higher rate of incident AF in dose dependent manner. Thus, assessing proteinuria by a simple urine dipstick test could provide a useful adjunct to risk assessment for AF in elderly population with DM.Juntae KimPil-Sung YangByoung-Eun ParkTae Soo KangSeong-Hoon LimSungsoo ChoSu-Yeon LeeMyung-Yong LeeGregory Y. H. LipDongmin KimBoyoung JoungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juntae Kim Pil-Sung Yang Byoung-Eun Park Tae Soo Kang Seong-Hoon Lim Sungsoo Cho Su-Yeon Lee Myung-Yong Lee Gregory Y. H. Lip Dongmin Kim Boyoung Joung Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
description	Abstract Diabetes mellitus (DM) is considered an independent risk factor for atrial fibrillation (AF). The excess risk in relation to the presence of proteinuria has not been well elucidated. Our aim was to determine the association between the incidence of AF and proteinuria in diabetic population. A total of 240,499 individuals aged ≥ 60 years from the Korea National Health Insurance Service-Senior cohort from 2004 to 2014 were included. 4.2% of individuals with DM and 3.7% of controls were diagnosed with AF during a median follow-up period of 7.2 years. Amongst controls (participants without proteinuria and DM), DM only, proteinuria only, and DM with proteinuria groups, the crude incidences of AF were 0.58, 0.70, 0.96, 1.24 per 100 person-years respectively. Compared with controls, the weighted risk of AF was increased by 11% (hazard ratio = 1.11, 95% confidence interval = 1.02–1.20, P = .001), 48% (hazard ratio = 1.48, 95% confidence interval = 1.30–1.69, P < .001), and 66% (hazard ratio = 1.66, 95% confidence interval = 1.26–2.18, P < .001) in the DM only, proteinuria only, and DM with proteinuria groups, respectively (P for trend < .001). Degree of proteinuria in diabetic patients was associated with a significantly higher rate of incident AF in dose dependent manner. Thus, assessing proteinuria by a simple urine dipstick test could provide a useful adjunct to risk assessment for AF in elderly population with DM.
format	article
author	Juntae Kim Pil-Sung Yang Byoung-Eun Park Tae Soo Kang Seong-Hoon Lim Sungsoo Cho Su-Yeon Lee Myung-Yong Lee Gregory Y. H. Lip Dongmin Kim Boyoung Joung
author_facet	Juntae Kim Pil-Sung Yang Byoung-Eun Park Tae Soo Kang Seong-Hoon Lim Sungsoo Cho Su-Yeon Lee Myung-Yong Lee Gregory Y. H. Lip Dongmin Kim Boyoung Joung
author_sort	Juntae Kim
title	Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
title_short	Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
title_full	Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
title_fullStr	Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
title_full_unstemmed	Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
title_sort	association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6119dba64bfe46c3b004479d2813dcf1
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Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study

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