α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.

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Bibliographic Details
Main Authors: Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/611e2baaf3784f32a5399bd5c6e6f8a6
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Summary:Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.