Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-in...
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Nature Portfolio
2016
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oai:doaj.org-article:6124de3f685042c7ac6137c260b386672021-12-02T17:32:37ZRelative rate and location of intra-host HIV evolution to evade cellular immunity are predictable10.1038/ncomms116602041-1723https://doaj.org/article/6124de3f685042c7ac6137c260b386672016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11660https://doaj.org/toc/2041-1723HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.John P. BartonNilu GoonetillekeThomas C. ButlerBruce D. WalkerAndrew J. McMichaelArup K. ChakrabortyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q John P. Barton Nilu Goonetilleke Thomas C. Butler Bruce D. Walker Andrew J. McMichael Arup K. Chakraborty Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
description |
HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons. |
format |
article |
author |
John P. Barton Nilu Goonetilleke Thomas C. Butler Bruce D. Walker Andrew J. McMichael Arup K. Chakraborty |
author_facet |
John P. Barton Nilu Goonetilleke Thomas C. Butler Bruce D. Walker Andrew J. McMichael Arup K. Chakraborty |
author_sort |
John P. Barton |
title |
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
title_short |
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
title_full |
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
title_fullStr |
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
title_full_unstemmed |
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable |
title_sort |
relative rate and location of intra-host hiv evolution to evade cellular immunity are predictable |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/6124de3f685042c7ac6137c260b38667 |
work_keys_str_mv |
AT johnpbarton relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable AT nilugoonetilleke relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable AT thomascbutler relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable AT brucedwalker relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable AT andrewjmcmichael relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable AT arupkchakraborty relativerateandlocationofintrahosthivevolutiontoevadecellularimmunityarepredictable |
_version_ |
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