Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-in...

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Autores principales: John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, Arup K. Chakraborty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6124de3f685042c7ac6137c260b38667
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spelling oai:doaj.org-article:6124de3f685042c7ac6137c260b386672021-12-02T17:32:37ZRelative rate and location of intra-host HIV evolution to evade cellular immunity are predictable10.1038/ncomms116602041-1723https://doaj.org/article/6124de3f685042c7ac6137c260b386672016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11660https://doaj.org/toc/2041-1723HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.John P. BartonNilu GoonetillekeThomas C. ButlerBruce D. WalkerAndrew J. McMichaelArup K. ChakrabortyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
description HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.
format article
author John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
author_facet John P. Barton
Nilu Goonetilleke
Thomas C. Butler
Bruce D. Walker
Andrew J. McMichael
Arup K. Chakraborty
author_sort John P. Barton
title Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_short Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_full Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_fullStr Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_full_unstemmed Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable
title_sort relative rate and location of intra-host hiv evolution to evade cellular immunity are predictable
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6124de3f685042c7ac6137c260b38667
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