A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure

Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectivel...

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Autores principales: Yufeng Yao, Qiulun Lu, Zhenkun Hu, Yubin Yu, Qiuyun Chen, Qing K. Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6125403f9aea40e3becc9eae807175b5
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spelling oai:doaj.org-article:6125403f9aea40e3becc9eae807175b52021-12-02T14:16:04ZA non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure10.1038/s41467-017-00171-w2041-1723https://doaj.org/article/6125403f9aea40e3becc9eae807175b52017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00171-whttps://doaj.org/toc/2041-1723Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectively treat cardiac hypertrophy and heart failure.Yufeng YaoQiulun LuZhenkun HuYubin YuQiuyun ChenQing K. WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yufeng Yao
Qiulun Lu
Zhenkun Hu
Yubin Yu
Qiuyun Chen
Qing K. Wang
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
description Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectively treat cardiac hypertrophy and heart failure.
format article
author Yufeng Yao
Qiulun Lu
Zhenkun Hu
Yubin Yu
Qiuyun Chen
Qing K. Wang
author_facet Yufeng Yao
Qiulun Lu
Zhenkun Hu
Yubin Yu
Qiuyun Chen
Qing K. Wang
author_sort Yufeng Yao
title A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
title_short A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
title_full A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
title_fullStr A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
title_full_unstemmed A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
title_sort non-canonical pathway regulates er stress signaling and blocks er stress-induced apoptosis and heart failure
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6125403f9aea40e3becc9eae807175b5
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