Rasmussen syndrome in a tropical environment: a study of six (6) observations

Abstract Background In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection...

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Autores principales: Carlos Othon Guelngar, Touré Mohamed Lamine, Barry Mamadou Ciré, Diakité Mamady, Konaté Mahadi, Djibo Hamani Bachir Abdoul, Sakadi Foksouna, Djibo Hassane Fatimata, Camara Naby, Kassa Dago François, Bah Fatimatou Korka, Camara Doussou, Millimono Victorine, Condé Salematou, Sakho Aminata, Diallo Mohamed Tafsir, Barry Souleymane Djigué, Diallo Mamadou Saliou, Soumah Fodé Mohamed, Sanni Yaya Aminou, Douna Granga Daouya, Rafkat Said Abdallah, Konaté Mamady, Diallo Souleymane Mbara, Cissé Fodé Abass, Cissé Amara
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Publicado: SpringerOpen 2021
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spelling oai:doaj.org-article:6126a58941174f47866c36c036f3af412021-11-28T12:13:39ZRasmussen syndrome in a tropical environment: a study of six (6) observations10.1186/s41983-021-00409-x1687-8329https://doaj.org/article/6126a58941174f47866c36c036f3af412021-11-01T00:00:00Zhttps://doi.org/10.1186/s41983-021-00409-xhttps://doaj.org/toc/1687-8329Abstract Background In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection is little known in sub-Saharan Africa as evidenced by the scarcity of publications. Results A retrospective, descriptive and analytical study of six (6) cases of Rasmussen syndrome, shows that it is an unrecognized disease in Africa. Men were more represented with a frequency of 67% with a young age. The clinical picture dominated by 100% seizures, mental deterioration and hemiparesis. The etiology is still questionable, probably autoimmune in our study. Conclusion Rasmussen syndrome accounts for 3% in 219 patients hospitalized for epileptic conditions. This study shows a clinical profile dominated by recurrent epileptic seizures refractory to the drugs Phenobarbital, Valproic Acid and Carbamazepine, the only antiepileptics available in the country. These results are valid for therapeutic and prognostic discussion.Carlos Othon GuelngarTouré Mohamed LamineBarry Mamadou CiréDiakité MamadyKonaté MahadiDjibo Hamani Bachir AbdoulSakadi FoksounaDjibo Hassane FatimataCamara NabyKassa Dago FrançoisBah Fatimatou KorkaCamara DoussouMillimono VictorineCondé SalematouSakho AminataDiallo Mohamed TafsirBarry Souleymane DjiguéDiallo Mamadou SaliouSoumah Fodé MohamedSanni Yaya AminouDouna Granga DaouyaRafkat Said AbdallahKonaté MamadyDiallo Souleymane MbaraCissé Fodé AbassCissé AmaraSpringerOpenarticleRasmussen syndromeChronic encephalitisEpilepsyHemiatrophySSANeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 57, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Rasmussen syndrome
Chronic encephalitis
Epilepsy
Hemiatrophy
SSA
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle Rasmussen syndrome
Chronic encephalitis
Epilepsy
Hemiatrophy
SSA
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Carlos Othon Guelngar
Touré Mohamed Lamine
Barry Mamadou Ciré
Diakité Mamady
Konaté Mahadi
Djibo Hamani Bachir Abdoul
Sakadi Foksouna
Djibo Hassane Fatimata
Camara Naby
Kassa Dago François
Bah Fatimatou Korka
Camara Doussou
Millimono Victorine
Condé Salematou
Sakho Aminata
Diallo Mohamed Tafsir
Barry Souleymane Djigué
Diallo Mamadou Saliou
Soumah Fodé Mohamed
Sanni Yaya Aminou
Douna Granga Daouya
Rafkat Said Abdallah
Konaté Mamady
Diallo Souleymane Mbara
Cissé Fodé Abass
Cissé Amara
Rasmussen syndrome in a tropical environment: a study of six (6) observations
description Abstract Background In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection is little known in sub-Saharan Africa as evidenced by the scarcity of publications. Results A retrospective, descriptive and analytical study of six (6) cases of Rasmussen syndrome, shows that it is an unrecognized disease in Africa. Men were more represented with a frequency of 67% with a young age. The clinical picture dominated by 100% seizures, mental deterioration and hemiparesis. The etiology is still questionable, probably autoimmune in our study. Conclusion Rasmussen syndrome accounts for 3% in 219 patients hospitalized for epileptic conditions. This study shows a clinical profile dominated by recurrent epileptic seizures refractory to the drugs Phenobarbital, Valproic Acid and Carbamazepine, the only antiepileptics available in the country. These results are valid for therapeutic and prognostic discussion.
format article
author Carlos Othon Guelngar
Touré Mohamed Lamine
Barry Mamadou Ciré
Diakité Mamady
Konaté Mahadi
Djibo Hamani Bachir Abdoul
Sakadi Foksouna
Djibo Hassane Fatimata
Camara Naby
Kassa Dago François
Bah Fatimatou Korka
Camara Doussou
Millimono Victorine
Condé Salematou
Sakho Aminata
Diallo Mohamed Tafsir
Barry Souleymane Djigué
Diallo Mamadou Saliou
Soumah Fodé Mohamed
Sanni Yaya Aminou
Douna Granga Daouya
Rafkat Said Abdallah
Konaté Mamady
Diallo Souleymane Mbara
Cissé Fodé Abass
Cissé Amara
author_facet Carlos Othon Guelngar
Touré Mohamed Lamine
Barry Mamadou Ciré
Diakité Mamady
Konaté Mahadi
Djibo Hamani Bachir Abdoul
Sakadi Foksouna
Djibo Hassane Fatimata
Camara Naby
Kassa Dago François
Bah Fatimatou Korka
Camara Doussou
Millimono Victorine
Condé Salematou
Sakho Aminata
Diallo Mohamed Tafsir
Barry Souleymane Djigué
Diallo Mamadou Saliou
Soumah Fodé Mohamed
Sanni Yaya Aminou
Douna Granga Daouya
Rafkat Said Abdallah
Konaté Mamady
Diallo Souleymane Mbara
Cissé Fodé Abass
Cissé Amara
author_sort Carlos Othon Guelngar
title Rasmussen syndrome in a tropical environment: a study of six (6) observations
title_short Rasmussen syndrome in a tropical environment: a study of six (6) observations
title_full Rasmussen syndrome in a tropical environment: a study of six (6) observations
title_fullStr Rasmussen syndrome in a tropical environment: a study of six (6) observations
title_full_unstemmed Rasmussen syndrome in a tropical environment: a study of six (6) observations
title_sort rasmussen syndrome in a tropical environment: a study of six (6) observations
publisher SpringerOpen
publishDate 2021
url https://doaj.org/article/6126a58941174f47866c36c036f3af41
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