Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

The present research work is designed to prepare and optimize butenafine (BT) loaded poly lactic co glycolic acid (PLGA) nanoparticles (BT-NPs). BT-NPs were prepared by emulsification probe sonication method using PLGA (A), PVA (B) as polymer and stabilizer, respectively. The optimum composition of...

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Autores principales:	Sultan Alshehri, Syed Sarim Imam
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	butenafine nanoparticles irritation study optimization antifungal activity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/61271efaa1004e01b68424c2251600f1
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spelling	oai:doaj.org-article:61271efaa1004e01b68424c2251600f12021-11-11T14:23:41ZFormulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel1071-75441521-046410.1080/10717544.2021.1995078https://doaj.org/article/61271efaa1004e01b68424c2251600f12021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/10717544.2021.1995078https://doaj.org/toc/1071-7544https://doaj.org/toc/1521-0464The present research work is designed to prepare and optimize butenafine (BT) loaded poly lactic co glycolic acid (PLGA) nanoparticles (BT-NPs). BT-NPs were prepared by emulsification probe sonication method using PLGA (A), PVA (B) as polymer and stabilizer, respectively. The optimum composition of BT-NPs was selected based on the point prediction method given by the Box Behnken design software. The optimized composition of BT-NPop showed a particle size of 267.21 ± 3.54 nm with an entrapment efficiency of 72.43 ± 3.11%. The optimum composition of BT-NPop was further converted into gel formulation using chitosan as a natural polymer. The prepared topical gel formulation (BT-NPopG) was further evaluated for gel characterization, drug release, permeation study, irritation, and antifungal studies. The prepared BT-NPopG formulation showed optimum pH, viscosity, spreadability, and drug content. The release and permeation study results revealed slow BT release (42.76 ± 2.87%) with significantly enhanced permeation across the egg membrane. The irritation study data showed negligible irritation with a cumulative score of 0.33. The antifungal study results conclude higher activity than marketed as well as pure BT. The overall conclusion of the results revealed BT-NPopG as an ideal delivery system to treat topical fungal infection.Sultan AlshehriSyed Sarim ImamTaylor & Francis Grouparticlebutenafinenanoparticlesirritation studyoptimizationantifungal activityTherapeutics. PharmacologyRM1-950ENDrug Delivery, Vol 28, Iss 1, Pp 2348-2360 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	butenafine nanoparticles irritation study optimization antifungal activity Therapeutics. Pharmacology RM1-950
spellingShingle	butenafine nanoparticles irritation study optimization antifungal activity Therapeutics. Pharmacology RM1-950 Sultan Alshehri Syed Sarim Imam Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
description	The present research work is designed to prepare and optimize butenafine (BT) loaded poly lactic co glycolic acid (PLGA) nanoparticles (BT-NPs). BT-NPs were prepared by emulsification probe sonication method using PLGA (A), PVA (B) as polymer and stabilizer, respectively. The optimum composition of BT-NPs was selected based on the point prediction method given by the Box Behnken design software. The optimized composition of BT-NPop showed a particle size of 267.21 ± 3.54 nm with an entrapment efficiency of 72.43 ± 3.11%. The optimum composition of BT-NPop was further converted into gel formulation using chitosan as a natural polymer. The prepared topical gel formulation (BT-NPopG) was further evaluated for gel characterization, drug release, permeation study, irritation, and antifungal studies. The prepared BT-NPopG formulation showed optimum pH, viscosity, spreadability, and drug content. The release and permeation study results revealed slow BT release (42.76 ± 2.87%) with significantly enhanced permeation across the egg membrane. The irritation study data showed negligible irritation with a cumulative score of 0.33. The antifungal study results conclude higher activity than marketed as well as pure BT. The overall conclusion of the results revealed BT-NPopG as an ideal delivery system to treat topical fungal infection.
format	article
author	Sultan Alshehri Syed Sarim Imam
author_facet	Sultan Alshehri Syed Sarim Imam
author_sort	Sultan Alshehri
title	Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
title_short	Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
title_full	Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
title_fullStr	Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
title_full_unstemmed	Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
title_sort	formulation and evaluation of butenafine loaded plga-nanoparticulate laden chitosan nano gel
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/61271efaa1004e01b68424c2251600f1
work_keys_str_mv	AT sultanalshehri formulationandevaluationofbutenafineloadedplgananoparticulateladenchitosannanogel AT syedsarimimam formulationandevaluationofbutenafineloadedplgananoparticulateladenchitosannanogel
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Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

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