Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells
The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS...
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MDPI AG
2021
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oai:doaj.org-article:612dc2636ef34bd8aa9a08d80d11a9e12021-11-25T17:15:34ZNon-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells10.3390/coatings111112842079-6412https://doaj.org/article/612dc2636ef34bd8aa9a08d80d11a9e12021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6412/11/11/1284https://doaj.org/toc/2079-6412The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N<sub>2</sub>/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time.Chih-Ying WuJiunn-Der LiaoChang-Han ChenHan LeeShyh-Hau WangBernard Haochih LiuCheng-Yi LeePei-Lin ShaoEnya LiMDPI AGarticlenon-thermal micro-plasmareactive oxygen/nitrogen speciescancer cell suppressionEngineering (General). Civil engineering (General)TA1-2040ENCoatings, Vol 11, Iss 1284, p 1284 (2021) |
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DOAJ |
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EN |
| topic |
non-thermal micro-plasma reactive oxygen/nitrogen species cancer cell suppression Engineering (General). Civil engineering (General) TA1-2040 |
| spellingShingle |
non-thermal micro-plasma reactive oxygen/nitrogen species cancer cell suppression Engineering (General). Civil engineering (General) TA1-2040 Chih-Ying Wu Jiunn-Der Liao Chang-Han Chen Han Lee Shyh-Hau Wang Bernard Haochih Liu Cheng-Yi Lee Pei-Lin Shao Enya Li Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| description |
The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N<sub>2</sub>/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time. |
| format |
article |
| author |
Chih-Ying Wu Jiunn-Der Liao Chang-Han Chen Han Lee Shyh-Hau Wang Bernard Haochih Liu Cheng-Yi Lee Pei-Lin Shao Enya Li |
| author_facet |
Chih-Ying Wu Jiunn-Der Liao Chang-Han Chen Han Lee Shyh-Hau Wang Bernard Haochih Liu Cheng-Yi Lee Pei-Lin Shao Enya Li |
| author_sort |
Chih-Ying Wu |
| title |
Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| title_short |
Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| title_full |
Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| title_fullStr |
Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| title_full_unstemmed |
Non-Thermal Reactive N<sub>2</sub>/He Plasma Exposure to Inhibit Epithelial Head and Neck Tumor Cells |
| title_sort |
non-thermal reactive n<sub>2</sub>/he plasma exposure to inhibit epithelial head and neck tumor cells |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/612dc2636ef34bd8aa9a08d80d11a9e1 |
| work_keys_str_mv |
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