Controlled release of simvastatin from biomimetic β-TCP drug delivery system.

Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means o...

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Autores principales:	Joshua Chou, Tomoko Ito, David Bishop, Makoto Otsuka, Besim Ben-Nissan, Bruce Milthorpe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61309dab47274cd2bc7bb2cf64a3ef46
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spelling	oai:doaj.org-article:61309dab47274cd2bc7bb2cf64a3ef462021-11-18T08:00:49ZControlled release of simvastatin from biomimetic β-TCP drug delivery system.1932-620310.1371/journal.pone.0054676https://doaj.org/article/61309dab47274cd2bc7bb2cf64a3ef462013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23349949/?tool=EBIhttps://doaj.org/toc/1932-6203Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin.Joshua ChouTomoko ItoDavid BishopMakoto OtsukaBesim Ben-NissanBruce MilthorpePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54676 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joshua Chou Tomoko Ito David Bishop Makoto Otsuka Besim Ben-Nissan Bruce Milthorpe Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
description	Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin.
format	article
author	Joshua Chou Tomoko Ito David Bishop Makoto Otsuka Besim Ben-Nissan Bruce Milthorpe
author_facet	Joshua Chou Tomoko Ito David Bishop Makoto Otsuka Besim Ben-Nissan Bruce Milthorpe
author_sort	Joshua Chou
title	Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
title_short	Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
title_full	Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
title_fullStr	Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
title_full_unstemmed	Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
title_sort	controlled release of simvastatin from biomimetic β-tcp drug delivery system.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/61309dab47274cd2bc7bb2cf64a3ef46
work_keys_str_mv	AT joshuachou controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem AT tomokoito controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem AT davidbishop controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem AT makotootsuka controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem AT besimbennissan controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem AT brucemilthorpe controlledreleaseofsimvastatinfrombiomimeticbtcpdrugdeliverysystem
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Controlled release of simvastatin from biomimetic β-TCP drug delivery system.

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