Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions

Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Surangrat Thongkorn, Songphon Kanlayaprasit, Pawinee Panjabud, Thanit Saeliw, Thanawin Jantheang, Kasidit Kasitipradit, Suthathip Sarobol, Depicha Jindatip, Valerie W. Hu, Tewin Tencomnao, Takako Kikkawa, Tatsuya Sato, Noriko Osumi, Tewarit Sarachana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61335a794d654c10913bb9e06dc44170
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61335a794d654c10913bb9e06dc44170
record_format	dspace
spelling	oai:doaj.org-article:61335a794d654c10913bb9e06dc441702021-12-02T14:01:19ZSex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions10.1038/s41598-020-80390-22045-2322https://doaj.org/article/61335a794d654c10913bb9e06dc441702021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80390-2https://doaj.org/toc/2045-2322Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuritogenesis, and learning/memory, and assessed these functions in the offspring of exposed pregnant rats. We found that prenatal BPA exposure increased neurite length, the number of primary neurites, and the number of neurite branches, but reduced the size of the hippocampal cell body in both sexes of the offspring. However, in utero exposure to BPA decreased the neuronal viability and the neuronal density in the hippocampus and impaired learning/memory only in the male offspring while the females were not affected. Interestingly, the expression of several ASD-related genes (e.g. Mief2, Eif3h, Cux1, and Atp8a1) in the hippocampus were dysregulated and showed a sex-specific correlation with neuronal viability, neuritogenesis, and/or learning/memory. The findings from this study suggest that prenatal BPA exposure disrupts ASD-related genes involved in neuronal viability, neuritogenesis, and learning/memory in a sex-dependent manner, and these genes may play an important role in the risk and the higher prevalence of ASD in males subjected to prenatal BPA exposure.Surangrat ThongkornSongphon KanlayaprasitPawinee PanjabudThanit SaeliwThanawin JantheangKasidit KasitipraditSuthathip SarobolDepicha JindatipValerie W. HuTewin TencomnaoTakako KikkawaTatsuya SatoNoriko OsumiTewarit SarachanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
description	Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated the effects of prenatal BPA exposure on ASD-related genes known to regulate neuronal viability, neuritogenesis, and learning/memory, and assessed these functions in the offspring of exposed pregnant rats. We found that prenatal BPA exposure increased neurite length, the number of primary neurites, and the number of neurite branches, but reduced the size of the hippocampal cell body in both sexes of the offspring. However, in utero exposure to BPA decreased the neuronal viability and the neuronal density in the hippocampus and impaired learning/memory only in the male offspring while the females were not affected. Interestingly, the expression of several ASD-related genes (e.g. Mief2, Eif3h, Cux1, and Atp8a1) in the hippocampus were dysregulated and showed a sex-specific correlation with neuronal viability, neuritogenesis, and/or learning/memory. The findings from this study suggest that prenatal BPA exposure disrupts ASD-related genes involved in neuronal viability, neuritogenesis, and learning/memory in a sex-dependent manner, and these genes may play an important role in the risk and the higher prevalence of ASD in males subjected to prenatal BPA exposure.
format	article
author	Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana
author_facet	Surangrat Thongkorn Songphon Kanlayaprasit Pawinee Panjabud Thanit Saeliw Thanawin Jantheang Kasidit Kasitipradit Suthathip Sarobol Depicha Jindatip Valerie W. Hu Tewin Tencomnao Takako Kikkawa Tatsuya Sato Noriko Osumi Tewarit Sarachana
author_sort	Surangrat Thongkorn
title	Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
title_short	Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
title_full	Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
title_fullStr	Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
title_full_unstemmed	Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
title_sort	sex differences in the effects of prenatal bisphenol a exposure on autism-related genes and their relationships with the hippocampus functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61335a794d654c10913bb9e06dc44170
work_keys_str_mv	AT surangratthongkorn sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT songphonkanlayaprasit sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT pawineepanjabud sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT thanitsaeliw sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT thanawinjantheang sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT kasiditkasitipradit sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT suthathipsarobol sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT depichajindatip sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT valeriewhu sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT tewintencomnao sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT takakokikkawa sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT tatsuyasato sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT norikoosumi sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions AT tewaritsarachana sexdifferencesintheeffectsofprenatalbisphenolaexposureonautismrelatedgenesandtheirrelationshipswiththehippocampusfunctions
_version_	1718392202353180672

Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions

Ejemplares similares