Structural changes in white matter lesion patients and their correlation with cognitive impairment

Jinfang Wang,1,2 Yi Liang,2 Hongyan Chen,1 Wanming Wang,2 Yanwen Wang,2 Ying Liang,3 Yumei Zhang1,4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital,...

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Autores principales:	Wang J, Liang Y, Chen H, Wang W, Wang Y, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	white matter lesions cognitive impairment gray matter density dementia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6136013cb99a4a6bbc48e893053db591
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spelling	oai:doaj.org-article:6136013cb99a4a6bbc48e893053db5912021-12-02T03:42:32ZStructural changes in white matter lesion patients and their correlation with cognitive impairment1178-2021https://doaj.org/article/6136013cb99a4a6bbc48e893053db5912019-05-01T00:00:00Zhttps://www.dovepress.com/structural-changes-in-white-matter-lesion-patients-and-their-correlati-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jinfang Wang,1,2 Yi Liang,2 Hongyan Chen,1 Wanming Wang,2 Yanwen Wang,2 Ying Liang,3 Yumei Zhang1,4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan 430000, China; 3School of Biomedical Engineering, Capital Medical University, Beijing 100050, China; 4Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Background: White matter lesions (WMLs) play a role in cognitive decline and dementia. Little is known about gray matter (GM) changes in WMLs. This study aimed to investigate GM changes in WML patients. Materials and methods: Correlations between altered structural volume and cognitive assessment scores were investigated. GM and white matter (WM) changes in 23 WML-vascular dementia (VaD) patients, 22 WML-non-dementia vascular cognitive impairment (VCIND) patients, and 23 healthy control (HC) subjects were examined. Gray matter density (GMD) was calculated by measuring local proportions of GM at thousands of homologous cortical locations. WM volume was obtained by fully automated software using voxel-based morphometry (VBM). Results: Widespread GMD was significantly lower in WML patients compared to control subjects in cortical and subcortical regions (p<0.05). Greatest differences were found in the bilateral anterior cingulate cortex, inferior frontal gyrus, insula, angular gyrus, caudate, precentral gyrus, and right middle temporal gyrus, right thalamus. Secondary region of interest (ROI) analysis indicated significantly greater GMD in the bilateral caudate among WML-VCIND patients (n=22) compared to HCs (p<0.05). There was a significant difference in WM volume between WML patients and control subjects (p<0.05). Greatest differences were located in the genu/body/splenium of the corpus callosum and superior corona radiata L, and posterior corona radiata L. There was a significant association between structural changes and cognitive scores (Montreal Cognitive Assessment [MoCA] score) (p<0.05). There was no significant correlation between structural changes and Mini Mental State Examination (MMSE) scores (p>0.05). Conclusion: GMD and WM volume were changed in WMLs, and the changes were detectable. Correlation between structural changes and cognitive function was promising in understanding the pathological and physiological mechanisms of WMLs. Keywords: white matter lesions, vascular dementia, gray matter density, dementiaWang JLiang YChen HWang WWang YLiang YZhang YDove Medical Pressarticlewhite matter lesionscognitive impairmentgray matter densitydementiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1355-1363 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	white matter lesions cognitive impairment gray matter density dementia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	white matter lesions cognitive impairment gray matter density dementia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang J Liang Y Chen H Wang W Wang Y Liang Y Zhang Y Structural changes in white matter lesion patients and their correlation with cognitive impairment
description	Jinfang Wang,1,2 Yi Liang,2 Hongyan Chen,1 Wanming Wang,2 Yanwen Wang,2 Ying Liang,3 Yumei Zhang1,4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan 430000, China; 3School of Biomedical Engineering, Capital Medical University, Beijing 100050, China; 4Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Background: White matter lesions (WMLs) play a role in cognitive decline and dementia. Little is known about gray matter (GM) changes in WMLs. This study aimed to investigate GM changes in WML patients. Materials and methods: Correlations between altered structural volume and cognitive assessment scores were investigated. GM and white matter (WM) changes in 23 WML-vascular dementia (VaD) patients, 22 WML-non-dementia vascular cognitive impairment (VCIND) patients, and 23 healthy control (HC) subjects were examined. Gray matter density (GMD) was calculated by measuring local proportions of GM at thousands of homologous cortical locations. WM volume was obtained by fully automated software using voxel-based morphometry (VBM). Results: Widespread GMD was significantly lower in WML patients compared to control subjects in cortical and subcortical regions (p<0.05). Greatest differences were found in the bilateral anterior cingulate cortex, inferior frontal gyrus, insula, angular gyrus, caudate, precentral gyrus, and right middle temporal gyrus, right thalamus. Secondary region of interest (ROI) analysis indicated significantly greater GMD in the bilateral caudate among WML-VCIND patients (n=22) compared to HCs (p<0.05). There was a significant difference in WM volume between WML patients and control subjects (p<0.05). Greatest differences were located in the genu/body/splenium of the corpus callosum and superior corona radiata L, and posterior corona radiata L. There was a significant association between structural changes and cognitive scores (Montreal Cognitive Assessment [MoCA] score) (p<0.05). There was no significant correlation between structural changes and Mini Mental State Examination (MMSE) scores (p>0.05). Conclusion: GMD and WM volume were changed in WMLs, and the changes were detectable. Correlation between structural changes and cognitive function was promising in understanding the pathological and physiological mechanisms of WMLs. Keywords: white matter lesions, vascular dementia, gray matter density, dementia
format	article
author	Wang J Liang Y Chen H Wang W Wang Y Liang Y Zhang Y
author_facet	Wang J Liang Y Chen H Wang W Wang Y Liang Y Zhang Y
author_sort	Wang J
title	Structural changes in white matter lesion patients and their correlation with cognitive impairment
title_short	Structural changes in white matter lesion patients and their correlation with cognitive impairment
title_full	Structural changes in white matter lesion patients and their correlation with cognitive impairment
title_fullStr	Structural changes in white matter lesion patients and their correlation with cognitive impairment
title_full_unstemmed	Structural changes in white matter lesion patients and their correlation with cognitive impairment
title_sort	structural changes in white matter lesion patients and their correlation with cognitive impairment
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6136013cb99a4a6bbc48e893053db591
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Structural changes in white matter lesion patients and their correlation with cognitive impairment

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