Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development

Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly emergent tick-borne bunyavirus first discovered in 2009 in China. SFTSV is a growing public health problem that may become more prominent owing to multiple competent tick-vectors and the expansion of human populations in a...

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Autores principales:	Nathen E. Bopp, Jaclyn A. Kaiser, Ashley E. Strother, Alan D. T. Barrett, David W. C. Beasley, Virginia Benassi, Gregg N. Milligan, Marie-Pierre Preziosi, Lisa M. Reece
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/613793a43e904ad3825e27bc910df27f
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spelling	oai:doaj.org-article:613793a43e904ad3825e27bc910df27f2021-12-02T12:42:26ZBaseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development10.1038/s41541-020-00257-52059-0105https://doaj.org/article/613793a43e904ad3825e27bc910df27f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41541-020-00257-5https://doaj.org/toc/2059-0105Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly emergent tick-borne bunyavirus first discovered in 2009 in China. SFTSV is a growing public health problem that may become more prominent owing to multiple competent tick-vectors and the expansion of human populations in areas where the vectors are found. Although tick-vectors of SFTSV are found in a wide geographic area, SFTS cases have only been reported from China, South Korea, Vietnam, and Japan. Patients with SFTS often present with high fever, leukopenia, and thrombocytopenia, and in some cases, symptoms can progress to severe outcomes, including hemorrhagic disease. Reported SFTSV case fatality rates range from ~5 to >30% depending on the region surveyed, with more severe disease reported in older individuals. Currently, treatment options for this viral infection remain mostly supportive as there are no licensed vaccines available and research is in the discovery stage. Animal models for SFTSV appear to recapitulate many facets of human disease, although none of the models mirror all clinical manifestations. There are insufficient data available on basic immunologic responses, the immune correlate(s) of protection, and the determinants of severe disease by SFTSV and related viruses. Many aspects of SFTSV virology and epidemiology are not fully understood, including a detailed understanding of the annual numbers of cases and the vertebrate host of the virus, so additional research on this disease is essential towards the development of vaccines and therapeutics.Nathen E. BoppJaclyn A. KaiserAshley E. StrotherAlan D. T. BarrettDavid W. C. BeasleyVirginia BenassiGregg N. MilliganMarie-Pierre PreziosiLisa M. ReeceNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nathen E. Bopp Jaclyn A. Kaiser Ashley E. Strother Alan D. T. Barrett David W. C. Beasley Virginia Benassi Gregg N. Milligan Marie-Pierre Preziosi Lisa M. Reece Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
description	Abstract Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly emergent tick-borne bunyavirus first discovered in 2009 in China. SFTSV is a growing public health problem that may become more prominent owing to multiple competent tick-vectors and the expansion of human populations in areas where the vectors are found. Although tick-vectors of SFTSV are found in a wide geographic area, SFTS cases have only been reported from China, South Korea, Vietnam, and Japan. Patients with SFTS often present with high fever, leukopenia, and thrombocytopenia, and in some cases, symptoms can progress to severe outcomes, including hemorrhagic disease. Reported SFTSV case fatality rates range from ~5 to >30% depending on the region surveyed, with more severe disease reported in older individuals. Currently, treatment options for this viral infection remain mostly supportive as there are no licensed vaccines available and research is in the discovery stage. Animal models for SFTSV appear to recapitulate many facets of human disease, although none of the models mirror all clinical manifestations. There are insufficient data available on basic immunologic responses, the immune correlate(s) of protection, and the determinants of severe disease by SFTSV and related viruses. Many aspects of SFTSV virology and epidemiology are not fully understood, including a detailed understanding of the annual numbers of cases and the vertebrate host of the virus, so additional research on this disease is essential towards the development of vaccines and therapeutics.
format	article
author	Nathen E. Bopp Jaclyn A. Kaiser Ashley E. Strother Alan D. T. Barrett David W. C. Beasley Virginia Benassi Gregg N. Milligan Marie-Pierre Preziosi Lisa M. Reece
author_facet	Nathen E. Bopp Jaclyn A. Kaiser Ashley E. Strother Alan D. T. Barrett David W. C. Beasley Virginia Benassi Gregg N. Milligan Marie-Pierre Preziosi Lisa M. Reece
author_sort	Nathen E. Bopp
title	Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
title_short	Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
title_full	Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
title_fullStr	Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
title_full_unstemmed	Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
title_sort	baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/613793a43e904ad3825e27bc910df27f
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Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development

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