Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic intervention in breast cancer.

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Auteurs principaux: Tania M. Puvirajesinghe, François Bertucci, Ashish Jain, Pierluigi Scerbo, Edwige Belotti, Stéphane Audebert, Michael Sebbagh, Marc Lopez, Andreas Brech, Pascal Finetti, Emmanuelle Charafe-Jauffret, Max Chaffanet, Rémy Castellano, Audrey Restouin, Sylvie Marchetto, Yves Collette, Anthony Gonçalvès, Ian Macara, Daniel Birnbaum, Laurent Kodjabachian, Terje Johansen, Jean-Paul Borg
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/613bb808db014e17b9b94d6f70ddaa1f
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Résumé:Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic intervention in breast cancer.

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