Women and Stroke: Different, yet Similar

Background: The impact of gender on acute ischemic stroke, in terms of presentation, severity, etiology, and outcome, is increasingly getting recognized. Here, we analyzed the gender-related differences in etiology and outcome of ischemic stroke in South India. Methods: Patients with first ever isch...

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Autores principales:	Nandini Mitta, Sapna Erat Sreedharan, Sankara P. Sarma, Padmavathy N. Sylaja
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	gender differences ischemic stroke stroke subtype stroke severity outcome Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/613e4b3e203e4a98b6f42bf8451ff945
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spelling	oai:doaj.org-article:613e4b3e203e4a98b6f42bf8451ff9452021-11-04T14:40:32ZWomen and Stroke: Different, yet Similar1664-545610.1159/000519540https://doaj.org/article/613e4b3e203e4a98b6f42bf8451ff9452021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519540https://doaj.org/toc/1664-5456Background: The impact of gender on acute ischemic stroke, in terms of presentation, severity, etiology, and outcome, is increasingly getting recognized. Here, we analyzed the gender-related differences in etiology and outcome of ischemic stroke in South India. Methods: Patients with first ever ischemic stroke within 1 week of onset presenting to the Comprehensive Stroke Care Centre, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India, were included in our study. Clinical and risk factor profile was documented. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) at onset, and stroke subtype classification was done using Trial of Org 10172 in Acute Ischemic Stroke criteria. The 3-month functional outcome was assessed using the modified Rankin Scale (mRS) with excellent outcome defined as an mRS ≤2. Results: Of the 742 patients, 250 (33.7%) were females. The age, clinical profile, and rate of reperfusion therapies did not differ between the genders. Women suffered more severe strokes (mean NIHSS 9.5 vs. 8.4, p = 0.03). While large artery atherosclerosis was more common in men (21.3% vs. 14.8%, p = 0.03), cardioembolic strokes secondary to rheumatic heart disease were more common in women (27.2% vs. 19.7%, p = 0.02). Men had a better 3-month functional outcome compared to women (68.6% vs. 61.2%, p = 0.04), but was not statistically significant after adjusting for confounders. Conclusion: Our data, from a single comprehensive stroke unit from South India, suggest that stroke in women are different, yet similar in many ways to men. Guideline-based treatment can result in comparable short-term outcomes, irrespective of admission stroke severity.Nandini MittaSapna Erat SreedharanSankara P. SarmaPadmavathy N. SylajaKarger Publishersarticlegender differencesischemic strokestroke subtypestroke severityoutcomeDiseases of the circulatory (Cardiovascular) systemRC666-701ENCerebrovascular Diseases Extra, Vol 11, Iss 3, Pp 106-111 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gender differences ischemic stroke stroke subtype stroke severity outcome Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	gender differences ischemic stroke stroke subtype stroke severity outcome Diseases of the circulatory (Cardiovascular) system RC666-701 Nandini Mitta Sapna Erat Sreedharan Sankara P. Sarma Padmavathy N. Sylaja Women and Stroke: Different, yet Similar
description	Background: The impact of gender on acute ischemic stroke, in terms of presentation, severity, etiology, and outcome, is increasingly getting recognized. Here, we analyzed the gender-related differences in etiology and outcome of ischemic stroke in South India. Methods: Patients with first ever ischemic stroke within 1 week of onset presenting to the Comprehensive Stroke Care Centre, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India, were included in our study. Clinical and risk factor profile was documented. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) at onset, and stroke subtype classification was done using Trial of Org 10172 in Acute Ischemic Stroke criteria. The 3-month functional outcome was assessed using the modified Rankin Scale (mRS) with excellent outcome defined as an mRS ≤2. Results: Of the 742 patients, 250 (33.7%) were females. The age, clinical profile, and rate of reperfusion therapies did not differ between the genders. Women suffered more severe strokes (mean NIHSS 9.5 vs. 8.4, p = 0.03). While large artery atherosclerosis was more common in men (21.3% vs. 14.8%, p = 0.03), cardioembolic strokes secondary to rheumatic heart disease were more common in women (27.2% vs. 19.7%, p = 0.02). Men had a better 3-month functional outcome compared to women (68.6% vs. 61.2%, p = 0.04), but was not statistically significant after adjusting for confounders. Conclusion: Our data, from a single comprehensive stroke unit from South India, suggest that stroke in women are different, yet similar in many ways to men. Guideline-based treatment can result in comparable short-term outcomes, irrespective of admission stroke severity.
format	article
author	Nandini Mitta Sapna Erat Sreedharan Sankara P. Sarma Padmavathy N. Sylaja
author_facet	Nandini Mitta Sapna Erat Sreedharan Sankara P. Sarma Padmavathy N. Sylaja
author_sort	Nandini Mitta
title	Women and Stroke: Different, yet Similar
title_short	Women and Stroke: Different, yet Similar
title_full	Women and Stroke: Different, yet Similar
title_fullStr	Women and Stroke: Different, yet Similar
title_full_unstemmed	Women and Stroke: Different, yet Similar
title_sort	women and stroke: different, yet similar
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/613e4b3e203e4a98b6f42bf8451ff945
work_keys_str_mv	AT nandinimitta womenandstrokedifferentyetsimilar AT sapnaeratsreedharan womenandstrokedifferentyetsimilar AT sankarapsarma womenandstrokedifferentyetsimilar AT padmavathynsylaja womenandstrokedifferentyetsimilar
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Women and Stroke: Different, yet Similar

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