Antimicrobial applications of nanotechnology: methods and literature

Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI, USAAbstract: The need for novel antibiotics comes from the relatively high incidence of bacterial infection and the growing resistance of bacteria to conventional antibiotics...

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Autores principales:	Seil JT, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/613ef602d29f4c84a328552a15756c94
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spelling	oai:doaj.org-article:613ef602d29f4c84a328552a15756c942021-12-02T07:22:51ZAntimicrobial applications of nanotechnology: methods and literature1176-91141178-2013https://doaj.org/article/613ef602d29f4c84a328552a15756c942012-06-01T00:00:00Zhttp://www.dovepress.com/antimicrobial-applications-of-nanotechnology-methods-and-literature-a10046https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI, USAAbstract: The need for novel antibiotics comes from the relatively high incidence of bacterial infection and the growing resistance of bacteria to conventional antibiotics. Consequently, new methods for reducing bacteria activity (and associated infections) are badly needed. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has become increasingly utilized for medical applications and is of great interest as an approach to killing or reducing the activity of numerous microorganisms. While some natural antibacterial materials, such as zinc and silver, possess greater antibacterial properties as particle size is reduced into the nanometer regime (due to the increased surface to volume ratio of a given mass of particles), the physical structure of a nanoparticle itself and the way in which it interacts with and penetrates into bacteria appears to also provide unique bactericidal mechanisms. A variety of techniques to evaluate bacteria viability, each with unique advantages and disadvantages, has been established and must be understood in order to determine the effectiveness of nanoparticles (diameter &le;100 nm) as antimicrobial agents. In addition to addressing those techniques, a review of select literature and a summary of bacteriostatic and bactericidal mechanisms are covered in this manuscript.Keywords: nanomaterial, nanoparticle, nanotechnology, bacteria, antibacterial, biofilmSeil JTWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2767-2781 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Seil JT Webster TJ Antimicrobial applications of nanotechnology: methods and literature
description	Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI, USAAbstract: The need for novel antibiotics comes from the relatively high incidence of bacterial infection and the growing resistance of bacteria to conventional antibiotics. Consequently, new methods for reducing bacteria activity (and associated infections) are badly needed. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has become increasingly utilized for medical applications and is of great interest as an approach to killing or reducing the activity of numerous microorganisms. While some natural antibacterial materials, such as zinc and silver, possess greater antibacterial properties as particle size is reduced into the nanometer regime (due to the increased surface to volume ratio of a given mass of particles), the physical structure of a nanoparticle itself and the way in which it interacts with and penetrates into bacteria appears to also provide unique bactericidal mechanisms. A variety of techniques to evaluate bacteria viability, each with unique advantages and disadvantages, has been established and must be understood in order to determine the effectiveness of nanoparticles (diameter &le;100 nm) as antimicrobial agents. In addition to addressing those techniques, a review of select literature and a summary of bacteriostatic and bactericidal mechanisms are covered in this manuscript.Keywords: nanomaterial, nanoparticle, nanotechnology, bacteria, antibacterial, biofilm
format	article
author	Seil JT Webster TJ
author_facet	Seil JT Webster TJ
author_sort	Seil JT
title	Antimicrobial applications of nanotechnology: methods and literature
title_short	Antimicrobial applications of nanotechnology: methods and literature
title_full	Antimicrobial applications of nanotechnology: methods and literature
title_fullStr	Antimicrobial applications of nanotechnology: methods and literature
title_full_unstemmed	Antimicrobial applications of nanotechnology: methods and literature
title_sort	antimicrobial applications of nanotechnology: methods and literature
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/613ef602d29f4c84a328552a15756c94
work_keys_str_mv	AT seiljt antimicrobialapplicationsofnanotechnologymethodsandliterature AT webstertj antimicrobialapplicationsofnanotechnologymethodsandliterature
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Antimicrobial applications of nanotechnology: methods and literature

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