Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure

Abstract Background Dysglycaemia is associated with overall cardiovascular disease even at prediabetes levels. The aim of this study was to explore the association between glucose levels and future risk of developing atrial fibrillation and heart failure, respectively. Methods In this prospective co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Viktor Lind, Niklas Hammar, Pia Lundman, Leif Friberg, Mats Talbäck, Göran Walldius, Anna Norhammar
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Prediabetes Impaired fasting glucose Dysglycaemia Diabetes Cardiovascular disease Atrial fibrillation Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/613f9f8ef7d74d5eacd816d3a8405d85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:613f9f8ef7d74d5eacd816d3a8405d85
record_format	dspace
spelling	oai:doaj.org-article:613f9f8ef7d74d5eacd816d3a8405d852021-11-28T12:14:06ZImpaired fasting glucose: a risk factor for atrial fibrillation and heart failure10.1186/s12933-021-01422-31475-2840https://doaj.org/article/613f9f8ef7d74d5eacd816d3a8405d852021-11-01T00:00:00Zhttps://doi.org/10.1186/s12933-021-01422-3https://doaj.org/toc/1475-2840Abstract Background Dysglycaemia is associated with overall cardiovascular disease even at prediabetes levels. The aim of this study was to explore the association between glucose levels and future risk of developing atrial fibrillation and heart failure, respectively. Methods In this prospective cohort study subjects from the Swedish AMORIS-cohort with fasting glucose from health examinations 1985–1996 without previous cardiovascular disease (N = 294,057) were followed to 31 December 2011 for incident atrial fibrillation or heart failure. Cox proportional hazard models with attained age as timescale and adjustments for sex, cholesterol, triglycerides, and socioeconomic status were used to estimate hazard ratios by glucose categorized groups (normal glucose 3.9–6.0 mmol/L, impaired fasting glucose; 6.1–6.9 mmol/L, undiagnosed diabetes ≥ 7.0 mmol/L, and diagnosed diabetes). Results During a mean follow-up time of 19.1 years 28,233 individuals developed atrial fibrillation and 25,604 developed heart failure. The HR for atrial fibrillation was 1.19 (95% confidence interval 1.13–1.26) for impaired fasting glucose, 1.23 (1.15–1.32) for undiagnosed diabetes and 1.30 (1.21–1.41) for diagnosed diabetes. Corresponding figures for heart failure were; 1.40 (1.33–1.48), 2.11 (1.99–2.23), 2.22 (2.08–2.36) respectively. In a subset with BMI data (19%), these associations were attenuated and for atrial fibrillation only remained statistically significant among subjects with diagnosed diabetes (HR 1.25; 1.02–1.53). Conclusions Fasting glucose at prediabetes levels is associated with development of atrial fibrillation and heart failure. To some extent increased BMI may drive this association.Viktor LindNiklas HammarPia LundmanLeif FribergMats TalbäckGöran WalldiusAnna NorhammarBMCarticlePrediabetesImpaired fasting glucoseDysglycaemiaDiabetesCardiovascular diseaseAtrial fibrillationDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiovascular Diabetology, Vol 20, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prediabetes Impaired fasting glucose Dysglycaemia Diabetes Cardiovascular disease Atrial fibrillation Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Prediabetes Impaired fasting glucose Dysglycaemia Diabetes Cardiovascular disease Atrial fibrillation Diseases of the circulatory (Cardiovascular) system RC666-701 Viktor Lind Niklas Hammar Pia Lundman Leif Friberg Mats Talbäck Göran Walldius Anna Norhammar Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
description	Abstract Background Dysglycaemia is associated with overall cardiovascular disease even at prediabetes levels. The aim of this study was to explore the association between glucose levels and future risk of developing atrial fibrillation and heart failure, respectively. Methods In this prospective cohort study subjects from the Swedish AMORIS-cohort with fasting glucose from health examinations 1985–1996 without previous cardiovascular disease (N = 294,057) were followed to 31 December 2011 for incident atrial fibrillation or heart failure. Cox proportional hazard models with attained age as timescale and adjustments for sex, cholesterol, triglycerides, and socioeconomic status were used to estimate hazard ratios by glucose categorized groups (normal glucose 3.9–6.0 mmol/L, impaired fasting glucose; 6.1–6.9 mmol/L, undiagnosed diabetes ≥ 7.0 mmol/L, and diagnosed diabetes). Results During a mean follow-up time of 19.1 years 28,233 individuals developed atrial fibrillation and 25,604 developed heart failure. The HR for atrial fibrillation was 1.19 (95% confidence interval 1.13–1.26) for impaired fasting glucose, 1.23 (1.15–1.32) for undiagnosed diabetes and 1.30 (1.21–1.41) for diagnosed diabetes. Corresponding figures for heart failure were; 1.40 (1.33–1.48), 2.11 (1.99–2.23), 2.22 (2.08–2.36) respectively. In a subset with BMI data (19%), these associations were attenuated and for atrial fibrillation only remained statistically significant among subjects with diagnosed diabetes (HR 1.25; 1.02–1.53). Conclusions Fasting glucose at prediabetes levels is associated with development of atrial fibrillation and heart failure. To some extent increased BMI may drive this association.
format	article
author	Viktor Lind Niklas Hammar Pia Lundman Leif Friberg Mats Talbäck Göran Walldius Anna Norhammar
author_facet	Viktor Lind Niklas Hammar Pia Lundman Leif Friberg Mats Talbäck Göran Walldius Anna Norhammar
author_sort	Viktor Lind
title	Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
title_short	Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
title_full	Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
title_fullStr	Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
title_full_unstemmed	Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
title_sort	impaired fasting glucose: a risk factor for atrial fibrillation and heart failure
publisher	BMC
publishDate	2021
url	https://doaj.org/article/613f9f8ef7d74d5eacd816d3a8405d85
work_keys_str_mv	AT viktorlind impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT niklashammar impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT pialundman impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT leiffriberg impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT matstalback impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT goranwalldius impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure AT annanorhammar impairedfastingglucoseariskfactorforatrialfibrillationandheartfailure
_version_	1718408143208185856

Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure

Ejemplares similares